Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1460314..1461148 Replicon chromosome
Accession NZ_CP059281
Organism Escherichia coli strain C9

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1J6XFW9
Locus tag H0272_RS06920 Protein ID WP_000854770.1
Coordinates 1460771..1461148 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1N885
Locus tag H0272_RS06915 Protein ID WP_001280950.1
Coordinates 1460314..1460682 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0272_RS06885 1455466..1457367 + 1902 Protein_1331 autotransporter adhesin Ag43 -
H0272_RS06890 1457438..1457596 + 159 WP_001323397.1 DUF905 family protein -
H0272_RS06895 1457751..1458569 + 819 WP_001234712.1 DUF945 domain-containing protein -
H0272_RS06900 1458911..1459375 + 465 WP_000855061.1 antirestriction protein -
H0272_RS06905 1459391..1459867 + 477 WP_001186779.1 RadC family protein -
H0272_RS06910 1459930..1460151 + 222 WP_001220314.1 DUF987 domain-containing protein -
H0272_RS06915 1460314..1460682 + 369 WP_001280950.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H0272_RS06920 1460771..1461148 + 378 WP_000854770.1 TA system toxin CbtA family protein Toxin
H0272_RS06925 1461145..1461633 + 489 WP_000761690.1 hypothetical protein -
H0272_RS06930 1461650..1461826 + 177 WP_000839286.1 DUF957 domain-containing protein -
H0272_RS06935 1461926..1462084 + 159 WP_001467148.1 hypothetical protein -
H0272_RS06940 1462448..1462624 + 177 Protein_1342 helix-turn-helix domain-containing protein -
H0272_RS06945 1463397..1465037 + 1641 WP_001332039.1 Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14196.37 Da        Isoelectric Point: 8.7438

>T168465 WP_000854770.1 NZ_CP059281:1460771-1461148 [Escherichia coli]
MKTLPDTHVRKVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T168465 NZ_CP076008:c5329439-5329056 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13737.56 Da        Isoelectric Point: 7.0268

>AT168465 WP_001280950.1 NZ_CP059281:1460314-1460682 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAFYPTSETKK

Download         Length: 369 bp

>AT168465 NZ_CP076008:c5329681-5329439 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6XFW9

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1N885

References