Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4356863..4357385 Replicon chromosome
Accession NZ_CP059119
Organism Escherichia coli strain Ec42

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag H0X94_RS20990 Protein ID WP_001105433.1
Coordinates 4356863..4357153 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag H0X94_RS20995 Protein ID WP_000212715.1
Coordinates 4357143..4357385 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0X94_RS20975 (4352026) 4352026..4353681 + 1656 WP_021523332.1 alpha,alpha-phosphotrehalase -
H0X94_RS20980 (4354075) 4354075..4356213 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
H0X94_RS20985 (4356398) 4356398..4356862 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
H0X94_RS20990 (4356863) 4356863..4357153 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H0X94_RS20995 (4357143) 4357143..4357385 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H0X94_RS21000 (4357577) 4357577..4357963 - 387 WP_001232246.1 cytochrome b562 -
H0X94_RS21005 (4358147) 4358147..4359499 - 1353 WP_001162173.1 metalloprotease PmbA -
H0X94_RS21010 (4359593) 4359593..4360144 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
H0X94_RS21015 (4360296) 4360296..4361669 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T168281 WP_001105433.1 NZ_CP059119:c4357153-4356863 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T168281 NZ_CP075697:c4744222-4744115 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT168281 WP_000212715.1 NZ_CP059119:c4357385-4357143 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT168281 NZ_CP075697:4744270-4744336 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References