Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1875904..1876739 | Replicon | chromosome |
| Accession | NZ_CP059119 | ||
| Organism | Escherichia coli strain Ec42 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A1X9TM58 |
| Locus tag | H0X94_RS09040 | Protein ID | WP_000854761.1 |
| Coordinates | 1875904..1876281 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | H0X94_RS09045 | Protein ID | WP_001295723.1 |
| Coordinates | 1876371..1876739 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H0X94_RS25725 (1871293) | 1871293..1871658 | - | 366 | WP_001282181.1 | EutP/PduV family microcompartment system protein | - |
| H0X94_RS09010 (1871929) | 1871929..1872318 | - | 390 | WP_001445118.1 | IS110 family transposase | - |
| H0X94_RS25730 (1872507) | 1872507..1872731 | - | 225 | Protein_1770 | transposase | - |
| H0X94_RS09015 (1872812) | 1872812..1873216 | + | 405 | WP_000839179.1 | transposase | - |
| H0X94_RS09020 (1873213) | 1873213..1873560 | + | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| H0X94_RS09025 (1873609) | 1873609..1875148 | + | 1540 | Protein_1773 | IS66-like element ISEc22 family transposase | - |
| H0X94_RS09030 (1875579) | 1875579..1875659 | - | 81 | Protein_1774 | hypothetical protein | - |
| H0X94_RS09035 (1875759) | 1875759..1875907 | - | 149 | Protein_1775 | DUF5983 family protein | - |
| H0X94_RS09040 (1875904) | 1875904..1876281 | - | 378 | WP_000854761.1 | TA system toxin CbtA family protein | Toxin |
| H0X94_RS09045 (1876371) | 1876371..1876739 | - | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| H0X94_RS09050 (1876902) | 1876902..1877123 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| H0X94_RS09055 (1877186) | 1877186..1877662 | - | 477 | WP_069067731.1 | RadC family protein | - |
| H0X94_RS09060 (1877677) | 1877677..1878150 | - | 474 | WP_000855059.1 | antirestriction protein | - |
| H0X94_RS09065 (1878492) | 1878492..1878914 | - | 423 | Protein_1781 | DUF945 domain-containing protein | - |
| H0X94_RS09070 (1879001) | 1879001..1879747 | - | 747 | WP_001016257.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
| H0X94_RS09075 (1879762) | 1879762..1881303 | - | 1542 | WP_001298859.1 | IS21-like element ISEc12 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1872812..1952515 | 79703 | |
| - | inside | IScluster/Tn | - | - | 1872812..1881303 | 8491 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14205.25 Da Isoelectric Point: 7.3249
>T168267 WP_000854761.1 NZ_CP059119:c1876281-1875904 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T168267 NZ_CP075697:c610407-610156 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT168267 WP_001295723.1 NZ_CP059119:c1876739-1876371 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT168267 NZ_CP075697:c610159-609905 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1X9TM58 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1NM52 |