Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3180364..3180981 Replicon chromosome
Accession NZ_CP059089
Organism Pantoea agglomerans strain AR1a

Toxin (Protein)


Gene name Hha Uniprot ID E0LTU7
Locus tag H0Z11_RS16030 Protein ID WP_003850458.1
Coordinates 3180766..3180981 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E0LTU8
Locus tag H0Z11_RS16025 Protein ID WP_003850455.1
Coordinates 3180364..3180741 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0Z11_RS15995 (H0Z11_15985) 3176671..3176925 + 255 WP_208002373.1 type B 50S ribosomal protein L31 -
H0Z11_RS16000 (H0Z11_15990) 3176937..3177077 + 141 WP_010255896.1 type B 50S ribosomal protein L36 -
H0Z11_RS16005 (H0Z11_15995) 3177123..3178001 - 879 WP_137228504.1 metal ABC transporter substrate-binding protein -
H0Z11_RS16010 (H0Z11_16000) 3178017..3178856 - 840 WP_031592170.1 metal ABC transporter permease -
H0Z11_RS16015 (H0Z11_16005) 3178853..3179521 - 669 WP_031592171.1 ABC transporter ATP-binding protein -
H0Z11_RS16020 (H0Z11_16010) 3179863..3180216 + 354 WP_137228497.1 hypothetical protein -
H0Z11_RS16025 (H0Z11_16015) 3180364..3180741 + 378 WP_003850455.1 Hha toxicity modulator TomB Antitoxin
H0Z11_RS16030 (H0Z11_16020) 3180766..3180981 + 216 WP_003850458.1 HHA domain-containing protein Toxin
H0Z11_RS16040 (H0Z11_16030) 3181388..3181699 + 312 WP_031592174.1 MGMT family protein -
H0Z11_RS16045 (H0Z11_16035) 3181739..3182296 - 558 WP_010255881.1 YbaY family lipoprotein -
H0Z11_RS16050 (H0Z11_16040) 3182487..3183350 + 864 WP_010255880.1 acyl-CoA thioesterase II -
H0Z11_RS16055 (H0Z11_16045) 3183401..3184687 - 1287 WP_208002374.1 ammonium transporter AmtB -
H0Z11_RS16060 (H0Z11_16050) 3184722..3185060 - 339 WP_003850469.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8510.90 Da        Isoelectric Point: 9.4825

>T168254 WP_003850458.1 NZ_CP059089:3180766-3180981 [Pantoea agglomerans]
MNKTLTKTDYLMRLRRCRSLDTLERVIEKNKYELPEDELAVFYSAADHRLAELTMNKLYDKVPGSVWKFVR

Download         Length: 216 bp

>T168254 NZ_CP075681:490248-490598 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14636.25 Da        Isoelectric Point: 4.3976

>AT168254 WP_003850455.1 NZ_CP059089:3180364-3180741 [Pantoea agglomerans]
MDEYSPKRHDIAQLKYLCESLFDDSMATLTDSHHGWVNDPTSESNLQLNDLIEHIASFTMNYKIKHVEDEALISQIDEYL
DDTFMLFSNYGVNSPDLQRWQRSAKRLFNLFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT168254 NZ_CP075681:489961-490242 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I5AGC3

Antitoxin

Source ID Structure
AlphaFold DB A0A1I5AG55

References