Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 66578..67113 Replicon plasmid pAR1aB
Accession NZ_CP059088
Organism Pantoea agglomerans strain AR1a

Toxin (Protein)


Gene name relE Uniprot ID A0A8X8DPA1
Locus tag H0Z11_RS00755 Protein ID WP_010257115.1
Coordinates 66826..67113 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H0Z11_RS00750 Protein ID WP_039387444.1
Coordinates 66578..66829 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0Z11_RS00735 (H0Z11_00735) 61928..63817 + 1890 WP_207874207.1 sigma-54-dependent Fis family transcriptional regulator -
H0Z11_RS00740 (H0Z11_00740) 63913..64863 + 951 WP_207874209.1 sulfonate ABC transporter substrate-binding protein -
H0Z11_RS00745 (H0Z11_00745) 65156..66289 + 1134 WP_083070622.1 glutathione-independent formaldehyde dehydrogenase -
H0Z11_RS00750 (H0Z11_00750) 66578..66829 + 252 WP_039387444.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H0Z11_RS00755 (H0Z11_00755) 66826..67113 + 288 WP_010257115.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H0Z11_RS00760 (H0Z11_00760) 67265..67495 + 231 Protein_61 ISNCY family transposase -
H0Z11_RS00765 (H0Z11_00765) 67515..67799 + 285 Protein_62 IS3 family transposase -
H0Z11_RS00770 (H0Z11_00770) 67896..68816 - 921 WP_069027204.1 Rpn family recombination-promoting nuclease/putative transposase -
H0Z11_RS00775 (H0Z11_00775) 69175..69984 - 810 WP_172607963.1 restriction endonuclease -
H0Z11_RS00780 (H0Z11_00780) 70536..70715 + 180 Protein_65 XRE family transcriptional regulator -
H0Z11_RS00785 (H0Z11_00785) 70996..71691 + 696 WP_115758304.1 haloacid dehalogenase type II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..160336 160336


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11173.08 Da        Isoelectric Point: 10.3856

>T168248 WP_010257115.1 NZ_CP059088:66826-67113 [Pantoea agglomerans]
VSYTVKFREEAFKEWQKLDKSLQQQFAKKLKKCCDNPHIPSARLRGIKDCYKIKLRASGFRLVYQVIDDQLVIAVVAVGK
RERSDVYHLASERMR

Download         Length: 288 bp

>T168248 NZ_CP075667:3198-3596 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9108.38 Da        Isoelectric Point: 3.9507

>AT168248 WP_039387444.1 NZ_CP059088:66578-66829 [Pantoea agglomerans]
MPNIILSDTSASVSELKKNPMATVNAGDGYPVAILNRNQPAFYCVPAELYEQMLDALDDQELVKLVSERSGQRLLDVDLD
ALL

Download         Length: 252 bp

>AT168248 NZ_CP075667:2971-3198 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References