Detailed information of TA system TA168103

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 454018..454659
• Replicon: chromosome
• Accession: NZ_CP059040
• Organism: Acinetobacter baumannii strain ATCC 19606

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: D0CD27
• Locus tag: H0N29_RS02170
• Protein ID: WP_000607073.1
• Coordinates: 454270..454659 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: H0N29_RS02165
• Protein ID: WP_011860336.1
• Coordinates: 454018..454263 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0N29_RS02145	449521..450528	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
H0N29_RS02150	450547..450924	+	378	WP_001216380.1	50S ribosomal protein L17	-
H0N29_RS02155	451106..452596	+	1491	WP_000415127.1	NAD(P)/FAD-dependent oxidoreductase	-
H0N29_RS02160	452646..453818	-	1173	WP_001190553.1	acyl-CoA dehydrogenase family protein	-
H0N29_RS02165	454018..454263	+	246	WP_011860336.1	succinate dehydrogenase assembly factor 2	Antitoxin
H0N29_RS02170	454270..454659	+	390	WP_000607073.1	membrane protein	Toxin
H0N29_RS02175	455429..456511	+	1083	WP_000049103.1	hypothetical protein	-
H0N29_RS02180	456590..457156	+	567	WP_000651536.1	rhombosortase	-
H0N29_RS02185	457344..459539	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15635.91 Da
• Isoelectric Point: 10.3890

>T168103 WP_000607073.1 NZ_CP059040:454270-454659 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T168103 NZ_CP075632:4430391-4430798 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9842.27 Da
• Isoelectric Point: 4.9001

>AT168103 WP_011860336.1 NZ_CP059040:454018-454263 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT168103 NZ_CP075632:4430144-4430410 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: D0CD27