Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 624104..624723 Replicon chromosome
Accession NZ_CP058940
Organism Klebsiella pneumoniae strain BA39649

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HBJ39_RS03190 Protein ID WP_002892050.1
Coordinates 624505..624723 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HBJ39_RS03185 Protein ID WP_002892066.1
Coordinates 624104..624478 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ39_RS03175 (619256) 619256..620449 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HBJ39_RS03180 (620472) 620472..623618 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HBJ39_RS03185 (624104) 624104..624478 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HBJ39_RS03190 (624505) 624505..624723 + 219 WP_002892050.1 HHA domain-containing protein Toxin
HBJ39_RS03195 (624886) 624886..625452 + 567 WP_002892030.1 maltose O-acetyltransferase -
HBJ39_RS03200 (625424) 625424..625564 - 141 WP_004147370.1 hypothetical protein -
HBJ39_RS03205 (625585) 625585..626055 + 471 WP_040182126.1 YlaC family protein -
HBJ39_RS03210 (626030) 626030..627481 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HBJ39_RS03215 (627582) 627582..628280 + 699 WP_209754051.1 GNAT family protein -
HBJ39_RS03220 (628277) 628277..628417 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HBJ39_RS03225 (628417) 628417..628680 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T167960 WP_002892050.1 NZ_CP058940:624505-624723 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T167960 NZ_CP075488:40935-41456 [Escherichia coli]
GTGAGCAATACGACGATCGGGATTTTCTCTGGAGAGAAAGATTATGATCTAAACGGTTTTGATTGCGGCGAAGAGTCGCT
AAACGCATTTTTGACCAACCACTTAAAAAGACAGCATGAAGGAAAAATTCTTCGCGCTTATGTGCTTTGCACTAAAGAAG
AAATACCAAAGGTATTAGGTTATTACACTTTGTCAGGCAGCTGCTTTGAGAAAGAAAACTTACCTTCAAAGAGTCAGCAA
AAGAAAGTGCCTTATCGGCATGTCCCAAGTATCACTTTAGGCAGACTGGCTTTGGACAAATCTCTTCAAGGTCAGGGGCT
TGGCTCAATGCTTGTAACTCACGCAATGCGTGTTGTGTACAATGCATCTCTTGCGGTAGGCATTCATGGGCTTTTCGTTG
AGGCGTTGAACGATAAAGCCAGGGCGTTTTATAAAAGTTTGGGCTTTATCCAGCTGGTTGGTAACAACGATCGTTCTTTG
TTCTATCCAACAAAATCTATCGAAAAATTGTTCGAAGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT167960 WP_002892066.1 NZ_CP058940:624104-624478 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT167960 NZ_CP075488:40658-40927 [Escherichia coli]
ATGTCCGCACTGAAAAAGCAGCGCATCGATTTGAGATTAACCGATGACGATAAAAGCATCATCGAGGAAGCTGCCGCAAT
GTCTAACCAGAGCATTACTCAGTTTATGGTTAGCAGTGCATCCGAACGTGCCGTGAAGGTGATAGAGCAACACCGTAGAC
TGGTTCTAAGTGAAGAGTCCTGGAATCTGGTTATGGATGCTATAAGCAATCCTCCGGCACCGAACGACAAGCTGAAACGA
GCTGCCAATCGTCTGAAAAGCATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References