Detailed information of TA system TA167830

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2649902..2651490
• Replicon: chromosome
• Accession: NZ_CP058869
• Organism: Klebsiella pneumoniae strain STLEFF_44

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HZT31_RS13145
• Protein ID: WP_064151580.1
• Coordinates: 2649902..2651224 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HZT31_RS13150
• Protein ID: WP_004176198.1
• Coordinates: 2651224..2651490 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT31_RS13130 (2644958)	2644958..2647459	+	2502	WP_064151582.1	fimbria/pilus outer membrane usher protein	-
HZT31_RS13135 (2647447)	2647447..2648451	+	1005	WP_064151581.1	fimbrial protein	-
HZT31_RS13140 (2648593)	2648593..2649885	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
HZT31_RS13145 (2649902)	2649902..2651224	-	1323	WP_064151580.1	type II toxin-antitoxin system HipA family toxin	Toxin
HZT31_RS13150 (2651224)	2651224..2651490	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HZT31_RS13155 (2651756)	2651756..2652082	-	327	WP_004176200.1	hydroxyisourate hydrolase	-
HZT31_RS13160 (2652079)	2652079..2652579	-	501	WP_064151579.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HZT31_RS13165 (2652557)	2652557..2653936	-	1380	WP_004184021.1	nucleobase:cation symporter-2 family protein	-
HZT31_RS13170 (2654282)	2654282..2655436	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
HZT31_RS13175 (2655417)	2655417..2656340	-	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T167830 WP_064151580.1 NZ_CP058869:c2651224-2649902 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
AHSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T167830 NZ_CP075470:64520-64801 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT167830 WP_004176198.1 NZ_CP058869:c2651490-2651224 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT167830 NZ_CP075470:64279-64530 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACTACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA