Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2525512..2526150 Replicon chromosome
Accession NZ_CP058796
Organism Shigella flexneri strain STLIN_8

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HZT12_RS12545 Protein ID WP_000813794.1
Coordinates 2525974..2526150 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HZT12_RS12540 Protein ID WP_001270286.1
Coordinates 2525512..2525928 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT12_RS12520 (2520664) 2520664..2521605 - 942 WP_112034129.1 ABC transporter permease -
HZT12_RS12525 (2521606) 2521606..2522619 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
HZT12_RS12530 (2522637) 2522637..2523782 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
HZT12_RS12535 (2524027) 2524027..2525433 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
HZT12_RS12540 (2525512) 2525512..2525928 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HZT12_RS12545 (2525974) 2525974..2526150 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HZT12_RS12550 (2526372) 2526372..2526602 + 231 WP_000494244.1 YncJ family protein -
HZT12_RS12555 (2526694) 2526694..2528655 - 1962 WP_089640461.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HZT12_RS12560 (2528728) 2528728..2529264 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
HZT12_RS12565 (2529356) 2529356..2530531 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T167545 WP_000813794.1 NZ_CP058796:c2526150-2525974 [Shigella flexneri]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T167545 NZ_CP075142:c24715-24317 [Salmonella enterica]
ATGCTGAAGTTTATGCTGGATACCAATATCTGTATCTTTACGATAAAAAACAAACCTGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGATCACCCTGATGGAGCTGATTTACGGCGCCGAAAAAAGCCAGATGCCCG
AAAGAAATCTCGCTGTGATAGAGGGGTTTGTTTCCCGACTTGATGTTCTGGATTATGACACGCCGGCCGCCACCCATACG
GGGCAGATCAGGGCAGAGCTTGCCCGTCAGGGACGCCCTGTCGGGCCATTCGATCAGATGATTGCCGGTCACGCACGCAG
CCGGGGACTGATTGTTGTCACGAACAACACCCGGGAGTTTGAACGTGTGGGTGGACTGAGAACTGAGGACTGGAACTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT167545 WP_001270286.1 NZ_CP058796:c2525928-2525512 [Shigella flexneri]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT167545 NZ_CP075142:c24942-24715 [Salmonella enterica]
ATGGAAACCAGCGTATTTCTCAGTAACCGAAGCCAGGCGGTCAGACTGCCAAAAGCAGTGGCATTGCCGGAACATGTAAA
ACGTGTGGAAGTTATCGCTGTCGGGCGAACCCGGATCATCACGCCAGCCGGAGAATCGTGGGATGAATGGTTCGACGGGA
ACAACGTCAGCGCCGATTTTATGGATAACCGGGAACAACCCTCTATGCAGGAACGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References