Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 253513..254344 Replicon chromosome
Accession NZ_CP058725
Organism Escherichia coli strain S171-1

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag HZS87_RS01160 Protein ID WP_000854814.1
Coordinates 253513..253887 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag HZS87_RS01165 Protein ID WP_001285585.1
Coordinates 253976..254344 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS87_RS01120 (248909) 248909..250075 + 1167 WP_024240938.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
HZS87_RS01125 (250194) 250194..250667 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
HZS87_RS01130 (250865) 250865..251923 + 1059 WP_001200891.1 FUSC family protein -
HZS87_RS01135 (252095) 252095..252424 + 330 WP_000450409.1 DUF496 family protein -
HZS87_RS01140 (252525) 252525..252659 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
HZS87_RS01145 (252779) 252779..252907 + 129 Protein_227 transposase domain-containing protein -
HZS87_RS01150 (253196) 253196..253276 - 81 Protein_228 hypothetical protein -
HZS87_RS01155 (253322) 253322..253516 - 195 WP_000988600.1 DUF5983 family protein -
HZS87_RS01160 (253513) 253513..253887 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
HZS87_RS01165 (253976) 253976..254344 - 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
HZS87_RS01170 (254418) 254418..254639 - 222 WP_000692346.1 DUF987 domain-containing protein -
HZS87_RS01175 (254708) 254708..255184 - 477 WP_001186725.1 RadC family protein -
HZS87_RS01180 (255200) 255200..255685 - 486 WP_000214415.1 antirestriction protein -
HZS87_RS01185 (255777) 255777..256598 - 822 WP_024172605.1 DUF932 domain-containing protein -
HZS87_RS01190 (256819) 256819..257229 - 411 WP_000846713.1 hypothetical protein -
HZS87_RS01195 (257245) 257245..257928 - 684 WP_000775500.1 hypothetical protein -
HZS87_RS01200 (258064) 258064..259134 - 1071 WP_148119577.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T167270 WP_000854814.1 NZ_CP058725:c253887-253513 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T167270 NZ_CP075108:c4169800-4169309 [Salmonella enterica]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT167270 WP_001285585.1 NZ_CP058725:c254344-253976 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT167270 NZ_CP075108:c4170090-4169797 [Salmonella enterica]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References