Detailed information of TA system TA167249

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1569981..1570816
• Replicon: chromosome
• Accession: NZ_CP058719
• Organism: Escherichia coli strain M159-1

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HZS86_RS07550
• Protein ID: WP_057109034.1
• Coordinates: 1569981..1570358 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A1E5MC43
• Locus tag: HZS86_RS07555
• Protein ID: WP_063112944.1
• Coordinates: 1570448..1570816 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS86_RS07530 (1566348)	1566348..1567886	-	1539	WP_001187177.1	lysine decarboxylation/transport transcriptional activator CadC	-
HZS86_RS07535 (1568635)	1568635..1569477	-	843	WP_001529559.1	DUF4942 domain-containing protein	-
HZS86_RS07540 (1569562)	1569562..1569759	-	198	WP_023563519.1	DUF957 domain-containing protein	-
HZS86_RS07545 (1569835)	1569835..1569984	-	150	Protein_1468	DUF5983 family protein	-
HZS86_RS07550 (1569981)	1569981..1570358	-	378	WP_057109034.1	TA system toxin CbtA family protein	Toxin
HZS86_RS07555 (1570448)	1570448..1570816	-	369	WP_063112944.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HZS86_RS07560 (1570866)	1570866..1571510	-	645	WP_045146861.1	hypothetical protein	-
HZS86_RS07565 (1571529)	1571529..1571750	-	222	WP_000692323.1	DUF987 domain-containing protein	-
HZS86_RS07570 (1571813)	1571813..1572289	-	477	WP_001186780.1	RadC family protein	-
HZS86_RS07575 (1572305)	1572305..1572790	-	486	WP_000213716.1	antirestriction protein	-
HZS86_RS07580 (1572882)	1572882..1573700	-	819	WP_096211214.1	DUF932 domain-containing protein	-
HZS86_RS07585 (1573801)	1573801..1573953	-	153	WP_001696589.1	DUF905 family protein	-
HZS86_RS07590 (1573959)	1573959..1574636	-	678	WP_063091580.1	hypothetical protein	-
HZS86_RS07595 (1574755)	1574755..1575639	-	885	WP_023563932.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13934.86 Da
• Isoelectric Point: 6.8517

>T167249 WP_057109034.1 NZ_CP058719:c1570358-1569981 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKQ

Nucleotide

• Length: 378 bp

>T167249 NZ_CP075106:c4185823-4185539 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCTGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13724.52 Da
• Isoelectric Point: 6.8270

>AT167249 WP_063112944.1 NZ_CP058719:c1570816-1570448 [Escherichia coli]
VSDTLPGTTHHDDNHDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT167249 NZ_CP075106:c4186055-4185813 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A1E5MC43