Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 228162..228816 Replicon chromosome
Accession NZ_CP058719
Organism Escherichia coli strain M159-1

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag HZS86_RS01100 Protein ID WP_000244777.1
Coordinates 228162..228569 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HZS86_RS01105 Protein ID WP_000354046.1
Coordinates 228550..228816 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS86_RS01080 (224119) 224119..225852 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
HZS86_RS01085 (225858) 225858..226568 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HZS86_RS01090 (226593) 226593..227489 - 897 WP_072643464.1 site-specific tyrosine recombinase XerD -
HZS86_RS01095 (227601) 227601..228122 + 522 WP_001055874.1 flavodoxin FldB -
HZS86_RS01100 (228162) 228162..228569 - 408 WP_000244777.1 protein YgfX Toxin
HZS86_RS01105 (228550) 228550..228816 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HZS86_RS01110 (229059) 229059..230039 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
HZS86_RS01115 (230235) 230235..230894 - 660 WP_000250274.1 hemolysin III family protein -
HZS86_RS01120 (231058) 231058..231369 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
HZS86_RS01125 (231414) 231414..232847 + 1434 WP_239802598.1 6-phospho-beta-glucosidase BglA -
HZS86_RS01130 (232904) 232904..233647 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T167243 WP_000244777.1 NZ_CP058719:c228569-228162 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T167243 NZ_CP075106:1947482-1947814 [Salmonella enterica]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCAGGTCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCCGTTGTTATTCCCGTCACCAGCGGTGGAAACTTCGCCCGCG
CAGCCGGTTTTACCGTCTCACTGGAGGGGGCGGGAACCAAAACAACGGGCGTGATCCGCTGCGACCAGCCCAGAACTATT
GATATGGGCGCCCGAAATGGTAAGCGACTGGAGCGCATACCCGACGCTGTCGTGAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT167243 WP_000354046.1 NZ_CP058719:c228816-228550 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT167243 NZ_CP075106:1947224-1947481 [Salmonella enterica]
ATGTATACCACTCGTCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGCTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGAGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References