Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3584718..3585411 Replicon chromosome
Accession NZ_CP058709
Organism Escherichia coli strain S163-2

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HZS88_RS17920 Protein ID WP_000415584.1
Coordinates 3584718..3585014 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HZS88_RS17925 Protein ID WP_000650107.1
Coordinates 3585016..3585411 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS88_RS17885 (3579806) 3579806..3580120 - 315 WP_000958598.1 putative quinol monooxygenase -
HZS88_RS17890 (3580151) 3580151..3580732 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HZS88_RS17895 (3581051) 3581051..3581383 + 333 WP_000917684.1 DUF2645 family protein -
HZS88_RS17900 (3581429) 3581429..3582778 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
HZS88_RS17905 (3582775) 3582775..3583434 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HZS88_RS17910 (3583586) 3583586..3583978 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HZS88_RS17915 (3584031) 3584031..3584513 + 483 WP_000183505.1 GyrI-like domain-containing protein -
HZS88_RS17920 (3584718) 3584718..3585014 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HZS88_RS17925 (3585016) 3585016..3585411 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HZS88_RS17930 (3585544) 3585544..3587151 + 1608 WP_063120833.1 ABC transporter substrate-binding protein -
HZS88_RS17935 (3587289) 3587289..3589547 + 2259 WP_072671900.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T167198 WP_000415584.1 NZ_CP058709:3584718-3585014 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T167198 NZ_CP075061:517902-518252 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT167198 WP_000650107.1 NZ_CP058709:3585016-3585411 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT167198 NZ_CP075061:517657-517908 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References