Detailed information of TA system TA167121

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 2780872..2781274
• Replicon: chromosome
• Accession: NZ_CP058671
• Organism: Salmonella enterica strain MS114

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: HWV51_RS13680
• Protein ID: WP_000994223.1
• Coordinates: 2781029..2781274 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	2780872..2781238 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HWV51_RS13660	2777595..2778269	+	675	Protein_2672	IS66-like element accessory protein TnpA	-
HWV51_RS13665	2778269..2778616	+	348	WP_000624622.1	IS66 family insertion sequence element accessory protein TnpB	-
HWV51_RS13670	2778636..2780206	+	1571	Protein_2674	IS66 family transposase	-
HWV51_RS13675	2780462..2780695	-	234	WP_129589482.1	hypothetical protein	-
-	2780872..2781238	-	367	-	-	Antitoxin
HWV51_RS13680	2781029..2781274	+	246	WP_000994223.1	hypothetical protein	Toxin
HWV51_RS13685	2781338..2781784	-	447	WP_000171103.1	hypothetical protein	-
HWV51_RS13690	2781781..2783280	-	1500	Protein_2678	RHS repeat-associated core domain-containing protein	-
HWV51_RS13695	2783361..2783588	+	228	WP_022630712.1	SymE family type I addiction module toxin	-
HWV51_RS13700	2783635..2784069	-	435	WP_000789494.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T167121 WP_000994223.1 NZ_CP058671:2781029-2781274 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T167121 NZ_CP074685:508422-508772 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAGAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Nucleotide

• Length: 367 bp

>AT167121 NZ_CP058671:c2781238-2780872 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACTGCGCCCCCCTCTCCCCG
GCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin