167119

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 1512074..1512596 Replicon chromosome
Accession NZ_CP058671
Organism Salmonella enterica strain MS114

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag HWV51_RS07360 Protein ID WP_000221345.1
Coordinates 1512312..1512596 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag HWV51_RS07355 Protein ID WP_000885424.1
Coordinates 1512074..1512322 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWV51_RS07325 (1507722) 1507722..1508021 + 300 WP_223229036.1 hypothetical protein -
HWV51_RS07330 (1508360) 1508360..1508692 - 333 WP_000253156.1 DUF1493 family protein -
HWV51_RS07335 (1509108) 1509108..1509215 - 108 Protein_1432 IS110 family transposase -
HWV51_RS07340 (1509629) 1509629..1510857 + 1229 WP_088895425.1 IS3-like element IS2 family transposase -
HWV51_RS07345 (1510916) 1510916..1511305 + 390 WP_001044696.1 hypothetical protein -
HWV51_RS07350 (1511308) 1511308..1511661 + 354 WP_000418733.1 hypothetical protein -
HWV51_RS07355 (1512074) 1512074..1512322 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HWV51_RS07360 (1512312) 1512312..1512596 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HWV51_RS07365 (1512767) 1512767..1513156 + 390 WP_052894255.1 RidA family protein -
HWV51_RS07370 (1513214) 1513214..1514287 - 1074 WP_000954681.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
HWV51_RS07375 (1514480) 1514480..1514968 - 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
HWV51_RS07380 (1515013) 1515013..1516521 + 1509 WP_000199403.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T167119 WP_000221345.1 NZ_CP058671:1512312-1512596 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T167119 NZ_CP074681:131301-131717 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT167119 WP_000885424.1 NZ_CP058671:1512074-1512322 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT167119 NZ_CP074681:131074-131304 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References