Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 2398280..2398836 Replicon chromosome
Accession NZ_CP058668
Organism Treponema sp. B152

Toxin (Protein)


Gene name relE Uniprot ID Q73QZ0
Locus tag HYB91_RS11240 Protein ID WP_002676650.1
Coordinates 2398280..2398561 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q73QZ1
Locus tag HYB91_RS11245 Protein ID WP_002676649.1
Coordinates 2398558..2398836 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYB91_RS11225 (HYB91_11200) 2393490..2395319 + 1830 WP_002676653.1 signal peptide peptidase SppA -
HYB91_RS11230 (HYB91_11205) 2395358..2396464 + 1107 WP_002666350.1 redox-regulated ATPase YchF -
HYB91_RS11235 (HYB91_11210) 2396647..2398203 - 1557 WP_044909998.1 hypothetical protein -
HYB91_RS11240 (HYB91_11215) 2398280..2398561 - 282 WP_002676650.1 type II toxin-antitoxin system YafQ family toxin Toxin
HYB91_RS11245 (HYB91_11220) 2398558..2398836 - 279 WP_002676649.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HYB91_RS11250 (HYB91_11225) 2398909..2399712 - 804 WP_002676647.1 class I SAM-dependent methyltransferase -
HYB91_RS11255 (HYB91_11230) 2399786..2401216 - 1431 WP_002676645.1 leucyl aminopeptidase -
HYB91_RS11260 (HYB91_11235) 2401412..2402311 + 900 WP_002666354.1 glutamate formimidoyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10774.68 Da        Isoelectric Point: 10.2467

>T167103 WP_002676650.1 NZ_CP058668:c2398561-2398280 [Treponema sp. B152]
MIYQLKKTSQFKASVKLAKKRGLNINLLEGIIEKLRTDTPLGVKHKNHQLSGQFKGIWECHIQPDWLLLYLKEENNLVMT
LVDTGTHSDIFKK

Download         Length: 282 bp

>T167103 NZ_CP074680:2375069-2376391 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10223.83 Da        Isoelectric Point: 6.2705

>AT167103 WP_002676649.1 NZ_CP058668:c2398836-2398558 [Treponema sp. B152]
MSTAVLQTRVDSQIKKEADDLFNALGIDTTTAIRLFLKQAINQQKIPFEILPPQKEFSPSVLAAIKEARQISCDASVKQY
KTAKELLADCEV

Download         Length: 279 bp

>AT167103 NZ_CP074680:2374803-2375069 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q73QZ0

Antitoxin

Source ID Structure
AlphaFold DB Q73QZ1

References