Detailed information of TA system TA167103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2398280..2398836
• Replicon: chromosome
• Accession: NZ_CP058668
• Organism: Treponema sp. B152

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q73QZ0
• Locus tag: HYB91_RS11240
• Protein ID: WP_002676650.1
• Coordinates: 2398280..2398561 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73QZ1
• Locus tag: HYB91_RS11245
• Protein ID: WP_002676649.1
• Coordinates: 2398558..2398836 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYB91_RS11225 (HYB91_11200)	2393490..2395319	+	1830	WP_002676653.1	signal peptide peptidase SppA	-
HYB91_RS11230 (HYB91_11205)	2395358..2396464	+	1107	WP_002666350.1	redox-regulated ATPase YchF	-
HYB91_RS11235 (HYB91_11210)	2396647..2398203	-	1557	WP_044909998.1	hypothetical protein	-
HYB91_RS11240 (HYB91_11215)	2398280..2398561	-	282	WP_002676650.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HYB91_RS11245 (HYB91_11220)	2398558..2398836	-	279	WP_002676649.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HYB91_RS11250 (HYB91_11225)	2398909..2399712	-	804	WP_002676647.1	class I SAM-dependent methyltransferase	-
HYB91_RS11255 (HYB91_11230)	2399786..2401216	-	1431	WP_002676645.1	leucyl aminopeptidase	-
HYB91_RS11260 (HYB91_11235)	2401412..2402311	+	900	WP_002666354.1	glutamate formimidoyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10774.68 Da
• Isoelectric Point: 10.2467

>T167103 WP_002676650.1 NZ_CP058668:c2398561-2398280 [Treponema sp. B152]
MIYQLKKTSQFKASVKLAKKRGLNINLLEGIIEKLRTDTPLGVKHKNHQLSGQFKGIWECHIQPDWLLLYLKEENNLVMT
LVDTGTHSDIFKK

Nucleotide

• Length: 282 bp

>T167103 NZ_CP074680:2375069-2376391 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10223.83 Da
• Isoelectric Point: 6.2705

>AT167103 WP_002676649.1 NZ_CP058668:c2398836-2398558 [Treponema sp. B152]
MSTAVLQTRVDSQIKKEADDLFNALGIDTTTAIRLFLKQAINQQKIPFEILPPQKEFSPSVLAAIKEARQISCDASVKQY
KTAKELLADCEV

Nucleotide

• Length: 279 bp

>AT167103 NZ_CP074680:2374803-2375069 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: Q73QZ0

Antitoxin

• AlphaFold DB: Q73QZ1