Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 82830..83664 Replicon chromosome
Accession NZ_CP058661
Organism Escherichia coli strain 005008

Toxin (Protein)


Gene name yeeV Uniprot ID W0S379
Locus tag HZR83_RS00380 Protein ID WP_000854808.1
Coordinates 83287..83664 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2J4HRK6
Locus tag HZR83_RS00375 Protein ID WP_001354276.1
Coordinates 82830..83198 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZR83_RS00355 80491..81309 + 819 WP_001234702.1 DUF945 domain-containing protein -
HZR83_RS00360 81400..81885 + 486 WP_000214319.1 antirestriction protein -
HZR83_RS00365 81901..82377 + 477 WP_001354275.1 RadC family protein -
HZR83_RS00370 82446..82667 + 222 WP_000692345.1 DUF987 domain-containing protein -
HZR83_RS00375 82830..83198 + 369 WP_001354276.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HZR83_RS00380 83287..83664 + 378 WP_000854808.1 type IV toxin-antitoxin system toxin CbtA Toxin
HZR83_RS00385 83661..84149 + 489 WP_000761645.1 hypothetical protein -
HZR83_RS00390 84161..84358 + 198 WP_000839241.1 DUF957 domain-containing protein -
HZR83_RS00395 84443..85288 + 846 WP_001280440.1 DUF4942 domain-containing protein -
HZR83_RS00405 85587..86093 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
HZR83_RS00410 86180..87526 + 1347 WP_000483767.1 IS4-like element IS4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 86198..87526 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13909.93 Da        Isoelectric Point: 7.9085

>T167057 WP_000854808.1 NZ_CP058661:83287-83664 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T167057 NZ_CP074663:365404-365679 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13649.47 Da        Isoelectric Point: 7.0261

>AT167057 WP_001354276.1 NZ_CP058661:82830-83198 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLSSCGYVYLAVYPTPKMKN

Download         Length: 369 bp

>AT167057 NZ_CP074663:365141-365401 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W0S379

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4HRK6

References