Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4909295..4909931 Replicon chromosome
Accession NZ_CP058644
Organism Pseudomonas yamanorum strain GZD14026

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HZF02_RS22505 Protein ID WP_179447572.1
Coordinates 4909295..4909699 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HZF02_RS22510 Protein ID WP_179447573.1
Coordinates 4909692..4909931 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZF02_RS22485 4904732..4905985 + 1254 WP_179447571.1 DUF1479 domain-containing protein -
HZF02_RS22490 4906403..4907653 + 1251 WP_167663725.1 ribonucleotide-diphosphate reductase subunit beta -
HZF02_RS22495 4907826..4908539 + 714 WP_155581507.1 HNH endonuclease -
HZF02_RS22500 4908612..4909253 + 642 WP_179451154.1 HAD-IB family hydrolase -
HZF02_RS22505 4909295..4909699 - 405 WP_179447572.1 type II toxin-antitoxin system VapC family toxin Toxin
HZF02_RS22510 4909692..4909931 - 240 WP_179447573.1 antitoxin Antitoxin
HZF02_RS22515 4910139..4911086 + 948 WP_179447574.1 hypothetical protein -
HZF02_RS22520 4911093..4911896 - 804 WP_179447575.1 sulfite exporter TauE/SafE family protein -
HZF02_RS22525 4912015..4912785 + 771 WP_155581500.1 helix-turn-helix transcriptional regulator -
HZF02_RS22530 4912888..4913265 + 378 WP_155581499.1 helix-turn-helix transcriptional regulator -
HZF02_RS22535 4913337..4913990 - 654 WP_179447576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - exlB 4906913..5127723 220810


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15154.51 Da        Isoelectric Point: 7.4204

>T166988 WP_179447572.1 NZ_CP058644:c4909699-4909295 [Pseudomonas yamanorum]
MIKYMLDTNIVIYIIKRRPIEMLEKFNANVGRMAISSITLAELMHGAEKSQFVEKNTRAMEDFTSRLEVIHYDDKAAFHY
GSIRSDLEKKGTPIGVNDLHIAGHARSSGLVLVTNNECEFSRVKGLIVENWIAA

Download         Length: 405 bp

>T166988 NZ_CP074579:16497-16847 [Pseudomonas syringae]
ATGAATACGTTTGCACTACGCTTTACCGAGGTTGCCCAGCAAAGCATTGAAGATCAGGTCGAGCACCTGGCTATCACTCA
GGGATTCTCATCAGCTGCTCAACGCATAGATTCCCTTATCGATGCCATCCAGGACAAGCTCCTGTCCACCCCTTTGGGCT
ACCCGGTCAGTCCTCAATTGAGTGAGCTGGGTGTACTGCACTATCGTGAGCTGAACACTGACGGATACCGGGTCTTTTAC
GAGGTGATGGATTCAGATGGTATTACCGGCATCGTCGTGTTGCTCGTATTAGGCGGGAAACAAAGTGTTGAACAGGCATT
GATACGCTATTGCCTCCATCAGCCTATATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9068.00 Da        Isoelectric Point: 4.0657

>AT166988 WP_179447573.1 NZ_CP058644:c4909931-4909692 [Pseudomonas yamanorum]
MSTGTVFTNNRTQNIRIPADMRFPEGVKTVEVRAVGRELIISPVENTWDSFFLASESVSEDFMEERAEQVQQERESLDD

Download         Length: 240 bp

>AT166988 NZ_CP074579:16236-16484 [Pseudomonas syringae]
ATGCGAGTTGAAACAATAAGCTACCTGAAACGCAACGCAGCCGACCTGCCTCTCGATGAGCCACTGGTTGTCACGCAAAA
CGGTGTCCCGGCCTACGTGGTGGAGTCTTACGCGGATCGTAAGCGCCGCGATGAGGCCATTGCCTTGGTAAAGCTCTTGG
CCATCAGTTCCCGCGAGTATGCCCAAGGCAAGCACTGTTCCACTGACGAACTCAAAGCCCGATTGAGCAGGAGGTTTGCC
CACAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References