Detailed information of TA system TA166899

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-ohsC/SymE(toxin)
• Location: 4414271..4414683
• Replicon: chromosome
• Accession: NZ_CP058596
• Organism: Escherichia coli strain UPEC_U013

Toxin (Protein)

• Gene name: symE
• Uniprot ID: Q8FA88
• Locus tag: HYE75_RS21250
• Protein ID: WP_000132630.1
• Coordinates: 4414342..4414683 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4414271..4414347 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYE75_RS21240	4410883..4412352	+	1470	WP_001315223.1	type I restriction-modification system subunit M	-
HYE75_RS21245	4412352..4414121	+	1770	WP_000110076.1	restriction endonuclease subunit S	-
-	4414271..4414347	-	77	NuclAT_6	-	Antitoxin
-	4414271..4414347	-	77	NuclAT_6	-	Antitoxin
-	4414271..4414347	-	77	NuclAT_6	-	Antitoxin
-	4414271..4414347	-	77	NuclAT_6	-	Antitoxin
-	4414271..4414347	-	77	NuclAT_7	-	Antitoxin
-	4414271..4414347	-	77	NuclAT_7	-	Antitoxin
-	4414271..4414347	-	77	NuclAT_7	-	Antitoxin
-	4414271..4414347	-	77	NuclAT_7	-	Antitoxin
HYE75_RS21250	4414342..4414683	+	342	WP_000132630.1	endoribonuclease SymE	Toxin
HYE75_RS21255	4414730..4416823	-	2094	WP_000648234.1	DUF262 domain-containing protein	-
HYE75_RS21260	4416921..4417001	-	81	WP_020233658.1	hypothetical protein	-
HYE75_RS21265	4417229..4418149	-	921	WP_000181195.1	Rpn family recombination-promoting nuclease/putative transposase	-
HYE75_RS21270	4418334..4419614	+	1281	WP_001304526.1	DUF445 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12294.13 Da
• Isoelectric Point: 8.4982

>T166899 WP_000132630.1 NZ_CP058596:4414342-4414683 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T166899 NZ_CP074541:4229975-4230193 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT166899 NZ_CP058596:c4414347-4414271 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0E0Y5T0

Antitoxin