Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1952061..1952892 Replicon chromosome
Accession NZ_CP058574
Organism Escherichia coli strain EC1

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag HYH05_RS09325 Protein ID WP_000854814.1
Coordinates 1952061..1952435 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag HYH05_RS09330 Protein ID WP_001285585.1
Coordinates 1952524..1952892 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYH05_RS09285 1947457..1948623 + 1167 WP_000830150.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
HYH05_RS09290 1948742..1949215 + 474 WP_001105389.1 DNA gyrase inhibitor SbmC -
HYH05_RS09295 1949413..1950471 + 1059 WP_001200891.1 FUSC family protein -
HYH05_RS09300 1950643..1950972 + 330 WP_000450409.1 DUF496 family protein -
HYH05_RS09305 1951073..1951255 - 183 WP_032140263.1 ethanolamine utilization protein -
HYH05_RS09310 1951327..1951455 + 129 Protein_1824 transposase domain-containing protein -
HYH05_RS09315 1951744..1951857 - 114 WP_001161660.1 DUF957 domain-containing protein -
HYH05_RS09320 1951870..1952064 - 195 WP_000988600.1 hypothetical protein -
HYH05_RS09325 1952061..1952435 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
HYH05_RS09330 1952524..1952892 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HYH05_RS09335 1952966..1953187 - 222 WP_000692323.1 DUF987 domain-containing protein -
HYH05_RS09340 1953250..1953726 - 477 WP_001186726.1 RadC family protein -
HYH05_RS09345 1953742..1954221 - 480 WP_000860087.1 antirestriction protein -
HYH05_RS09350 1954303..1955121 - 819 WP_021568933.1 DUF945 domain-containing protein -
HYH05_RS09355 1955221..1955454 - 234 WP_001119729.1 DUF905 family protein -
HYH05_RS09360 1955533..1955988 - 456 WP_000581504.1 hypothetical protein -
HYH05_RS09365 1956064..1956906 - 843 Protein_1835 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T166840 WP_000854814.1 NZ_CP058574:c1952435-1952061 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T166840 NZ_CP074523:350588-350935 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT166840 WP_001285585.1 NZ_CP058574:c1952892-1952524 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT166840 NZ_CP074523:350935-351234 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References