Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4792477..4792993 Replicon chromosome
Accession NZ_CP058361
Organism Klebsiella pneumoniae strain KP77

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag HYD36_RS23450 Protein ID WP_004178374.1
Coordinates 4792477..4792761 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HYD36_RS23455 Protein ID WP_002886901.1
Coordinates 4792751..4792993 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYD36_RS23425 (4787873) 4787873..4788136 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
HYD36_RS23430 (4788266) 4788266..4788439 + 174 WP_032414379.1 hypothetical protein -
HYD36_RS23435 (4788442) 4788442..4789185 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HYD36_RS23440 (4789542) 4789542..4791680 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HYD36_RS23445 (4792009) 4792009..4792473 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HYD36_RS23450 (4792477) 4792477..4792761 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HYD36_RS23455 (4792751) 4792751..4792993 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HYD36_RS23460 (4793071) 4793071..4794981 - 1911 WP_009486549.1 PRD domain-containing protein -
HYD36_RS23465 (4795004) 4795004..4796158 - 1155 WP_023287050.1 lactonase family protein -
HYD36_RS23470 (4796225) 4796225..4796965 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T166733 WP_004178374.1 NZ_CP058361:c4792761-4792477 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T166733 NZ_CP074412:c5717662-5717315 [Pseudomonas viridiflava]
GTGAAGCGGCCCGGATTCAATCGCGCGGATATCGTTCGCATCAACCTCAATCCAACCGCTGGCCGAGAACAGCAGGGCGA
TTTTCGTCCCGCGTTGGTGCTGACGCCAGCCGCGTATAACGTCTCCGGCCTTGCGATCGTTGCGCCTATCACCCAGGGTG
GCGATTTTGCGCGTTATGCGGGGTTCGCTGTTCCTTTGAGTGGGTCGGGCACCGAGACTCAGGGTGTCGTTCTGTGTAAT
CAGATTCGCACGGTTGATCTGCAAGCGCGTGGCGCGAAGCGTATCGAGTCAGCCCCCGATGTTGTGATCAATGATGCGCT
GGCCCGCGTACAGGCACTCTTTGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT166733 WP_002886901.1 NZ_CP058361:c4792993-4792751 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT166733 NZ_CP074412:c5717913-5717659 [Pseudomonas viridiflava]
ATGGAAGTCAAAATTCAGCAGTGGGGCAATAGCGCAGCAATCAGATTGCCAGCCAATGTGCTCAAGCAGATGAGCCTGGT
CAGCGGCGATGTGCTGGTGCTGGATGTTTCCAGCGAAGTGATGACGCTCAAGCCTGCCAAGGCCAGACTGCATTACCAAC
TGACCGACCTTATGGCCCAATGCGATTTGAATGCGTCCGAGCCAGAGGAGTTGGCTGGTTGGAACACCATGCAACCCACA
GGGCGTGAAGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References