Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3333929..3334589 Replicon chromosome
Accession NZ_CP058353
Organism Serratia marcescens strain ESE2014

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HW877_RS16110 Protein ID WP_016927037.1
Coordinates 3334236..3334589 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HW877_RS16105 Protein ID WP_244757703.1
Coordinates 3333929..3334231 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW877_RS16085 (HW877_16075) 3329539..3330453 - 915 WP_048797036.1 branched-chain amino acid ABC transporter permease -
HW877_RS16090 (HW877_16080) 3330577..3331695 - 1119 WP_016927040.1 branched-chain amino acid ABC transporter substrate-binding protein -
HW877_RS16100 (HW877_16090) 3332300..3333508 - 1209 WP_244757702.1 aldose 1-epimerase family protein -
HW877_RS16105 (HW877_16095) 3333929..3334231 - 303 WP_244757703.1 XRE family transcriptional regulator Antitoxin
HW877_RS16110 (HW877_16100) 3334236..3334589 - 354 WP_016927037.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HW877_RS16115 (HW877_16105) 3335028..3336323 + 1296 WP_033639874.1 MFS transporter -
HW877_RS16120 (HW877_16110) 3336351..3337157 + 807 WP_048796852.1 substrate-binding domain-containing protein -
HW877_RS16125 (HW877_16115) 3337132..3338031 - 900 WP_244757704.1 LysR family transcriptional regulator -
HW877_RS16130 (HW877_16120) 3338136..3338501 - 366 WP_004935528.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13433.33 Da        Isoelectric Point: 8.4803

>T166664 WP_016927037.1 NZ_CP058353:c3334589-3334236 [Serratia marcescens]
VWEIKTTDAFDHWFRSLSDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQCRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDGMIQVADREFTNWLNTLNEKE

Download         Length: 354 bp

>T166664 NZ_CP074366:c2895644-2895267 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCCCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACATAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11049.91 Da        Isoelectric Point: 6.4738

>AT166664 WP_244757703.1 NZ_CP058353:c3334231-3333929 [Serratia marcescens]
MGRTLEQLIADEKSEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYELVL

Download         Length: 303 bp

>AT166664 NZ_CP074366:c2896065-2895691 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References