Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 704065..704570 Replicon chromosome
Accession NZ_CP058331
Organism Pseudomonas aeruginosa strain ACR22

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HWQ50_RS03265 Protein ID WP_003083773.1
Coordinates 704065..704346 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HWQ50_RS03270 Protein ID WP_003083775.1
Coordinates 704343..704570 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ50_RS03240 699316..700665 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
HWQ50_RS03245 700714..701400 + 687 WP_003083762.1 FadR family transcriptional regulator -
HWQ50_RS03250 701501..702235 + 735 WP_003117208.1 GntR family transcriptional regulator -
HWQ50_RS03255 702439..702825 + 387 WP_014602345.1 aegerolysin family protein -
HWQ50_RS03260 702857..703765 - 909 WP_003083769.1 LysR family transcriptional regulator -
HWQ50_RS03265 704065..704346 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HWQ50_RS03270 704343..704570 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HWQ50_RS03275 704746..705366 - 621 WP_003101226.1 hypothetical protein -
HWQ50_RS03280 705467..705967 + 501 WP_003101228.1 LEA type 2 family protein -
HWQ50_RS03285 706040..706381 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HWQ50_RS03290 706463..707890 - 1428 WP_003083784.1 GABA permease -
HWQ50_RS03295 708059..709552 - 1494 WP_023109527.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T166573 WP_003083773.1 NZ_CP058331:c704346-704065 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T166573 NZ_CP074354:2618839-2618946 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGTTCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT166573 WP_003083775.1 NZ_CP058331:c704570-704343 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT166573 NZ_CP074354:c2618783-2618727 [Escherichia coli]
TCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References