Detailed information of TA system TA166426

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3551648..3552270
• Replicon: chromosome
• Accession: NZ_CP058272
• Organism: Acinetobacter sp. MYb10

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CQZ96_RS16640
• Protein ID: WP_105714473.1
• Coordinates: 3551875..3552270 (+)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CQZ96_RS16635
• Protein ID: WP_105714474.1
• Coordinates: 3551648..3551878 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CQZ96_RS16625	3549139..3550302	+	1164	WP_056515669.1	acyl-CoA dehydrogenase family protein	-
CQZ96_RS16630	3550375..3551544	+	1170	WP_004817883.1	acyl-CoA dehydrogenase family protein	-
CQZ96_RS16635	3551648..3551878	+	231	WP_105714474.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CQZ96_RS16640	3551875..3552270	+	396	WP_105714473.1	type II toxin-antitoxin system VapC family toxin	Toxin
CQZ96_RS16645	3552352..3552954	-	603	WP_105714472.1	TetR/AcrR family transcriptional regulator	-
CQZ96_RS16650	3553121..3554911	+	1791	WP_105714471.1	DUF1446 domain-containing protein	-
CQZ96_RS16655	3554996..3555919	+	924	WP_166781834.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (7-44)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14812.18 Da
• Isoelectric Point: 6.7173

>T166426 WP_105714473.1 NZ_CP058272:3551875-3552270 [Acinetobacter sp. MYb10]
VIYLLDTNICIYIINNKPAHVFEKFKQYQLGQLSISSISASELAFGVEKSGSLRNKNALDKFLVPLDVLPYDENAIWHYA
KLRQSLQSKGQMIGSLDMLIAAHALALDTVLVTNNMKEFERIDGLKLENWV

Nucleotide

• Length: 396 bp

>T166426 NZ_CP074149:c1129817-1129599 [Enterobacter sp. JBIWA008]
ATGTCTGATAAACCACTCACAAAGTTCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTTGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TAACAATGAATAAGCTGTATGACAAAATTCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8806.12 Da
• Isoelectric Point: 4.6096

>AT166426 WP_105714474.1 NZ_CP058272:3551648-3551878 [Acinetobacter sp. MYb10]
MEVAKIFQSGRSQAIRLPKAFRFEGKEVVVKHFGNGVLLLPLNNPWEIMQEAVFEFEDGFLLEREDQGIQSREELL

Nucleotide

• Length: 231 bp

>AT166426 NZ_CP074149:c1130219-1129845 [Enterobacter sp. JBIWA008]
ATGGACGAGTACTCGCCAAAAAGGCATGATATTGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAATGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGACT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTGTCCTGTTAA