Detailed information of TA system TA166425

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 291880..292531
• Replicon: chromosome
• Accession: NZ_CP058272
• Organism: Acinetobacter sp. MYb10

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A6A1RRY2
• Locus tag: CQZ96_RS01350
• Protein ID: WP_004719695.1
• Coordinates: 291880..292236 (+)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CQZ96_RS01355
• Protein ID: WP_105712463.1
• Coordinates: 292229..292531 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CQZ96_RS01340	288083..289231	+	1149	WP_105712461.1	phospholipase A	-
CQZ96_RS01345	289611..291482	-	1872	WP_171287879.1	ABC transporter ATP-binding protein/permease	-
CQZ96_RS01350	291880..292236	+	357	WP_004719695.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CQZ96_RS01355	292229..292531	+	303	WP_105712463.1	helix-turn-helix transcriptional regulator	Antitoxin
CQZ96_RS01360	292649..292936	-	288	WP_105712464.1	hypothetical protein	-
CQZ96_RS01365	292933..294495	-	1563	WP_105712465.1	PepSY domain-containing protein	-
CQZ96_RS01370	294499..294777	-	279	WP_056511720.1	hypothetical protein	-
CQZ96_RS01375	294838..296997	-	2160	WP_105712466.1	TonB-dependent siderophore receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (14-89)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13522.52 Da
• Isoelectric Point: 6.4642

>T166425 WP_004719695.1 NZ_CP058272:291880-292236 [Acinetobacter sp. MYb10]
MWTVITTDLFNEWLEQQDDSTQEKVLAALVVLQQLGPSLGRPLVDTVNDSKFTNMKELRVQHRGKPLRAFFIFDPLRQAI
VLCIGNKGGKKRFYKEMLDIAEQQYELHLSTLGDQSNG

Nucleotide

• Length: 357 bp

>T166425 NZ_CP074149:c625205-624684 [Enterobacter sp. JBIWA008]
GTGAACGACGTGAAGATAGGGATTTTTTCAGAAGACGTTGAGTACGACCTAAGCCAGTTCGACTGCGGAGAAGAGAGCCT
TAATACCTTTCTGGCGGAGCACCTGAAACGCCAGCATCGTGGAAAGTTTTTGCGGGGTTATGTCCTCACCACACGAGAGC
CAAAACCGCGTATTCTGGGCTATTACACGCTCTCCGGAAGCTGTTTTGAAAAGGCTTACCTGCCCTCAAAAACTCAGCAA
AAACGTATTCCTTATAAAAATGTGCCGAGCGTCACCCTTGGCCGTCTGGCGATTGATAAACGTATTCAGGGGCAAGGCTA
TGGAGAATTACTCGTCATTCATGCCATGAAGACCGTTTATTTGGCCTCCTTTGCCGTCGGCATTCACGGCCTGTTTGTTG
AAGCACTCAACCATAAAGCCAAAGAGTTTTACCTCAAAATGGGGTTCATACCGCTCCTGGCCGAGAATGAATTCACGCTG
TTCTTACCGACTAAAACCTTTGAGAGCGTGTTTGAAGAGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11371.23 Da
• Isoelectric Point: 6.7300

>AT166425 WP_105712463.1 NZ_CP058272:292229-292531 [Acinetobacter sp. MYb10]
MAKILQELLAGRSPESQDRIQKMADELRLQTQLHLIREELEISQKELAEILGIKQPSLSAIENRGHDLKISTIKKYVEAM
GGKLRIDVELPTGKHIEFNV

Nucleotide

• Length: 303 bp

>AT166425 NZ_CP074149:c625478-625209 [Enterobacter sp. JBIWA008]
ATGTCAGCACTGAAGAAACAGCGCATCGATCTCCGGTTAACCGAAGATGACAAAAACATGATCGAAGAAGCGGCGGCAAT
GACAAACCAGTCGATTTCACAATTCATGGTCAGCACAGCCTCTGAACGCGCAGCAGAGGTAATTGACCAGCACCGCCGCC
TGGTCCTTAGCGAAGCATCCTGGAATACGGTGATGGATGCCATCAGCAATCCGCCTGCGCCAAATGACCGCCTGAAGCGA
GCGGCTAAGCGTCTCCTGGATATGGAGTAA

Structures

Toxin

• AlphaFold DB: A0A6A1RRY2