Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2228653..2229197 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag HWS75_RS10410 Protein ID WP_003409896.1
Coordinates 2228653..2228949 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag HWS75_RS10415 Protein ID WP_003409899.1
Coordinates 2228946..2229197 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS10355 2223686..2224036 - 351 WP_003409871.1 hypothetical protein -
HWS75_RS10360 2224047..2224949 - 903 WP_003409874.1 hypothetical protein -
HWS75_RS10365 2224970..2225161 - 192 WP_003409876.1 hypothetical protein -
HWS75_RS10370 2225162..2225458 - 297 WP_003409877.1 hypothetical protein -
HWS75_RS10375 2225698..2225913 + 216 WP_003409878.1 antitoxin -
HWS75_RS10380 2225910..2226221 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
HWS75_RS10385 2226195..2226716 - 522 WP_003904745.1 hypothetical protein -
HWS75_RS10390 2226691..2227068 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
HWS75_RS10395 2227110..2227559 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
HWS75_RS10400 2227556..2228101 + 546 WP_003409891.1 SecB-like chaperone -
HWS75_RS10405 2227990..2228604 - 615 WP_003901296.1 hypothetical protein -
HWS75_RS10410 2228653..2228949 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HWS75_RS10415 2228946..2229197 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HWS75_RS10420 2229184..2229678 + 495 WP_003899099.1 hypothetical protein -
HWS75_RS10425 2229838..2230245 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
HWS75_RS10430 2230249..2230521 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HWS75_RS10435 2230554..2231774 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
HWS75_RS10440 2232673..2233470 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T166351 WP_003409896.1 NZ_CP058236:c2228949-2228653 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T166351 NZ_CP074137:4854559-4854834 [Serratia sp. JSRIV006]
ATGCAGGTTGTCTGGTCAGATCATGCGTTGCAGGATTTAGAGCGGTTGCGCGAATTTATTGCCAATGTCAATCCAGAAGC
AGCAGCACAGGTGCTTCAATCACTGGTGCTTGCCCCCGCTAACCTGCTGACGCATTCACGGATGGGACCCGCGCTGGCAA
GGTATGAACCACGGGAAGTGCGTCGTCTGATCGTCGGTAACTATGAAATGCACTACGAACTTAAAGTTAACGCGCTCTAC
ATGTTACGTGTTTGGCATACGCGGGAAAATCGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT166351 WP_003409899.1 NZ_CP058236:c2229197-2228946 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT166351 NZ_CP074137:4854278-4854559 [Serratia sp. JSRIV006]
ATGGGACAATCTGTAACACGCGTTATCACTGCCCATATACCTGTTGAAATGGCAGAGAAGATCGACGAACTGGCTGCAAA
CTATGATCGTTCTCGTGGCTGGATCGTCAAACAGGCCTTGGCTGCGATAATTGAGCAAGAAGAGAGCCGCCATTACATGA
TCTTGCAGGGGCTGGCTGATGTGGATGCGGGTAGAGTGGTGGAACAAGCCGATGTATTGAAATGGGTGAATAGCCTTAAC
AATGACACGCCACTTCCTGTCCCGCAGTCAGGTCAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References