Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3586120..3586741 Replicon chromosome
Accession NZ_CP058157
Organism Enterobacter hormaechei strain RHBSTW-00086

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HV061_RS17215 Protein ID WP_015571250.1
Coordinates 3586523..3586741 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HV061_RS17210 Protein ID WP_006809850.1
Coordinates 3586120..3586494 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV061_RS17200 3581248..3582441 + 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV061_RS17205 3582464..3585610 + 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
HV061_RS17210 3586120..3586494 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HV061_RS17215 3586523..3586741 + 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HV061_RS17220 3586949..3587500 + 552 WP_063199700.1 maltose O-acetyltransferase -
HV061_RS17225 3587617..3588084 + 468 WP_022647269.1 hypothetical protein -
HV061_RS17230 3588056..3589516 - 1461 WP_023299463.1 PLP-dependent aminotransferase family protein -
HV061_RS17235 3589619..3590329 + 711 WP_148741996.1 GNAT family N-acetyltransferase -
HV061_RS17240 3590326..3590466 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV061_RS17245 3590469..3590729 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T165954 WP_015571250.1 NZ_CP058157:3586523-3586741 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T165954 NZ_CP074005:c3969828-3969541 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTGGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCG
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGTCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT165954 WP_006809850.1 NZ_CP058157:3586120-3586494 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT165954 NZ_CP074005:c3969554-3969252 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATCTGACGAAGATATTGATTACAGCGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References