Detailed information of TA system TA165946

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 897853..898510
• Replicon: chromosome
• Accession: NZ_CP058157
• Organism: Enterobacter hormaechei strain RHBSTW-00086

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: HV061_RS04325
• Protein ID: WP_063202187.1
• Coordinates: 898100..898510 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: G8LDB7
• Locus tag: HV061_RS04320
• Protein ID: WP_003863437.1
• Coordinates: 897853..898119 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV061_RS04305	894398..895129	-	732	WP_022649308.1	MurR/RpiR family transcriptional regulator	-
HV061_RS04310	895396..896055	+	660	WP_063201518.1	hemolysin III family protein	-
HV061_RS04315	896578..897558	-	981	WP_181237594.1	tRNA-modifying protein YgfZ	-
HV061_RS04320	897853..898119	+	267	WP_003863437.1	FAD assembly factor SdhE	Antitoxin
HV061_RS04325	898100..898510	+	411	WP_063202187.1	protein YgfX	Toxin
HV061_RS04330	898512..899033	-	522	WP_063202184.1	flavodoxin FldB	-
HV061_RS04335	899135..900031	+	897	WP_003863442.1	site-specific tyrosine recombinase XerD	-
HV061_RS04340	900060..900773	+	714	WP_022649304.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
HV061_RS04345	900779..902512	+	1734	WP_063202181.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16268.16 Da
• Isoelectric Point: 10.7426

>T165946 WP_063202187.1 NZ_CP058157:898100-898510 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLCRLIVQQPTQE

Nucleotide

• Length: 411 bp

>T165946 NZ_CP074005:1876976-1877230 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10526.96 Da
• Isoelectric Point: 4.8310

>AT165946 WP_003863437.1 NZ_CP058157:897853-898119 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Nucleotide

• Length: 267 bp

>AT165946 NZ_CP074005:1876728-1876979 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A837F8P5