Detailed information of TA system TA165936

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA(toxin)
• Location: 3029489..3031272
• Replicon: chromosome
• Accession: NZ_CP058153
• Organism: Enterobacter hormaechei strain RHBSTW-00105

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HV071_RS14570
• Protein ID: WP_047053382.1
• Coordinates: 3029489..3030838 (+)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HV071_RS14575
• Protein ID: WP_047053381.1
• Coordinates: 3030835..3031272 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV071_RS14545	3025312..3026247	-	936	WP_003859306.1	tRNA dihydrouridine(16) synthase DusC	-
HV071_RS14550	3026416..3026811	+	396	WP_023295055.1	CidA/LrgA family protein	-
HV071_RS14555	3026808..3027503	+	696	WP_015572322.1	CidB/LrgB family autolysis modulator	-
HV071_RS14560	3027632..3028516	+	885	WP_047053384.1	cytidine deaminase	-
HV071_RS14565	3028644..3029354	+	711	WP_003859314.1	outer membrane permeability protein SanA	-
HV071_RS14570	3029489..3030838	+	1350	WP_047053382.1	type II toxin-antitoxin system HipA family toxin	Toxin
HV071_RS14575	3030835..3031272	+	438	WP_047053381.1	helix-turn-helix domain-containing protein	Antitoxin
HV071_RS14580	3031311..3032321	-	1011	WP_003859318.1	galactose/methyl galactoside ABC transporter permease MglC	-
HV071_RS14585	3032337..3033857	-	1521	WP_003859320.1	galactose/methyl galactoside ABC transporter ATP-binding protein MglA	-
HV071_RS14590	3033937..3034935	-	999	WP_017383382.1	galactose/glucose ABC transporter substrate-binding protein MglB	-
HV071_RS14595	3035231..3036253	-	1023	WP_047053378.1	HTH-type transcriptional regulator GalS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-406)

Antitoxin

• Cro/C1-type helix-turn-helix domain (78-129)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 51132.76 Da
• Isoelectric Point: 4.6556

>T165936 WP_047053382.1 NZ_CP058153:3029489-3030838 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLTCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFHYIPDKLSRWGLL

Nucleotide

• Length: 1350 bp

>T165936 NZ_CP074002:c90253-89975 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGT
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTGCCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCCGTGGGGAAAAGTGTAT
ATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 16161.57 Da
• Isoelectric Point: 10.5154

>AT165936 WP_047053381.1 NZ_CP058153:3030835-3031272 [Enterobacter hormaechei]
MKTSNEAESELLQTLAQVRSVNKKRHHDEAEDPDKPSVVKRQRVSQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADIINKIFKPFGLQTGLVPVSKSLIASLFS

Nucleotide

• Length: 438 bp

>AT165936 NZ_CP074002:c90522-90253 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCAAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGATAAATGA