Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2285322..2286061 Replicon chromosome
Accession NZ_CP058153
Organism Enterobacter hormaechei strain RHBSTW-00105

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV071_RS11030 Protein ID WP_045329830.1
Coordinates 2285322..2285807 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HV071_RS11035 Protein ID WP_047050951.1
Coordinates 2285795..2286061 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV071_RS11010 2281475..2282233 - 759 WP_047050948.1 trans-aconitate 2-methyltransferase -
HV071_RS11015 2282318..2282902 - 585 WP_047050949.1 NUDIX domain-containing protein -
HV071_RS11020 2282989..2283747 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
HV071_RS11025 2283852..2285144 + 1293 WP_047050950.1 glycoside hydrolase -
HV071_RS11030 2285322..2285807 - 486 WP_045329830.1 GNAT family N-acetyltransferase Toxin
HV071_RS11035 2285795..2286061 - 267 WP_047050951.1 DUF1778 domain-containing protein Antitoxin
HV071_RS11040 2286125..2287054 - 930 WP_047050986.1 LysR family transcriptional regulator -
HV071_RS11045 2287184..2288572 + 1389 WP_047050952.1 MFS transporter -
HV071_RS11050 2288594..2289589 - 996 WP_047050954.1 DUF2891 domain-containing protein -
HV071_RS11055 2289599..2290585 - 987 WP_047050955.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17512.18 Da        Isoelectric Point: 9.9658

>T165926 WP_045329830.1 NZ_CP058153:c2285807-2285322 [Enterobacter hormaechei]
VGRVTAPEPLSSAHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T165926 NZ_CP074001:1996248-1996351 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10089.51 Da        Isoelectric Point: 4.4857

>AT165926 WP_047050951.1 NZ_CP058153:c2286061-2285795 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVANDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT165926 NZ_CP074001:c1996389-1996118 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References