Detailed information of TA system TA165924

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1570277..1571190
• Replicon: chromosome
• Accession: NZ_CP058153
• Organism: Enterobacter hormaechei strain RHBSTW-00105

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HV071_RS07440
• Protein ID: WP_047052345.1
• Coordinates: 1570277..1570750 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HV071_RS07445
• Protein ID: WP_047052347.1
• Coordinates: 1570747..1571190 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV071_RS07420	1566436..1567746	+	1311	WP_181238460.1	type I-F CRISPR-associated protein Csy1	-
HV071_RS07425	1567743..1568678	+	936	WP_047052340.1	type I-F CRISPR-associated protein Csy2	-
HV071_RS07430	1568692..1569690	+	999	WP_047052342.1	type I-F CRISPR-associated protein Csy3	-
HV071_RS07435	1569700..1570254	+	555	WP_047052344.1	type I-F CRISPR-associated endoribonuclease Cas6/Csy4	-
HV071_RS07440	1570277..1570750	-	474	WP_047052345.1	RES domain-containing protein	Toxin
HV071_RS07445	1570747..1571190	-	444	WP_047052347.1	DUF2384 domain-containing protein	Antitoxin
HV071_RS07450	1572962..1573180	-	219	WP_002211347.1	translation initiation factor IF-1	-
HV071_RS07455	1573465..1574169	-	705	WP_047052381.1	leucyl/phenylalanyl-tRNA--protein transferase	-
HV071_RS07460	1574215..1575936	-	1722	WP_003858307.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-144)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17570.95 Da
• Isoelectric Point: 5.1151

>T165924 WP_047052345.1 NZ_CP058153:c1570750-1570277 [Enterobacter hormaechei]
MIFYRLVTGRFASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHVRKDTVLNQYQLFSINIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPAFRKALNSVELLPFDFDTRLAEKTAP

Nucleotide

• Length: 474 bp

>T165924 NZ_CP074001:1770183-1770434 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGCCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16502.77 Da
• Isoelectric Point: 6.4819

>AT165924 WP_047052347.1 NZ_CP058153:c1571190-1570747 [Enterobacter hormaechei]
MRTWVPAQRSADNTLWRYAGLPASRGMRLIEYLNQGLPVSVLDNIHEWTDMSKAEILRVTGINERNVARRKSTGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQLPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT165924 NZ_CP074001:1770431-1770685 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CATTGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA