Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 327696..328292 Replicon chromosome
Accession NZ_CP058153
Organism Enterobacter hormaechei strain RHBSTW-00105

Toxin (Protein)


Gene name PumA Uniprot ID A0A837F9W8
Locus tag HV071_RS01585 Protein ID WP_023315213.1
Coordinates 327990..328292 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A837FG03
Locus tag HV071_RS01580 Protein ID WP_022650216.1
Coordinates 327696..327983 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV071_RS01575 326068..327699 + 1632 WP_003860350.1 Na/Pi cotransporter family protein -
HV071_RS01580 327696..327983 - 288 WP_022650216.1 putative addiction module antidote protein Antitoxin
HV071_RS01585 327990..328292 - 303 WP_023315213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV071_RS01590 328490..329362 + 873 WP_022646725.1 23S rRNA pseudouridine(2604) synthase RluF -
HV071_RS01595 329363..329635 - 273 WP_047052050.1 DUF3811 domain-containing protein -
HV071_RS01600 329686..330630 - 945 WP_032627014.1 ketopantoate/pantoate/pantothenate transporter PanS -
HV071_RS01605 330724..332073 - 1350 WP_045344657.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.21 Da        Isoelectric Point: 10.1042

>T165921 WP_023315213.1 NZ_CP058153:c328292-327990 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T165921 NZ_CP074001:694298-694594 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10087.57 Da        Isoelectric Point: 5.7807

>AT165921 WP_022650216.1 NZ_CP058153:c327983-327696 [Enterobacter hormaechei]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp

>AT165921 NZ_CP074001:694596-694991 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F9W8

Antitoxin

Source ID Structure
AlphaFold DB A0A837FG03

References