Detailed information of TA system TA165920

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 101101..101820
• Replicon: chromosome
• Accession: NZ_CP058153
• Organism: Enterobacter hormaechei strain RHBSTW-00105

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HV071_RS00520
• Protein ID: WP_023315132.1
• Coordinates: 101101..101421 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HV071_RS00525
• Protein ID: WP_045307488.1
• Coordinates: 101455..101820 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV071_RS00485	96336..97217	+	882	WP_047050719.1	helix-turn-helix domain-containing protein	-
HV071_RS00490	97282..97581	-	300	WP_045335986.1	XRE family transcriptional regulator	-
HV071_RS00495	97578..97928	-	351	WP_047050720.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HV071_RS00500	98201..98453	-	253	Protein_99	DNA-binding protein	-
HV071_RS00505	98556..98897	-	342	WP_006812446.1	SymE family type I addiction module toxin	-
HV071_RS00510	99034..99210	+	177	WP_071962261.1	toxin-antitoxin system HicB family antitoxin	-
HV071_RS00515	99250..100806	-	1557	WP_047050722.1	hypothetical protein	-
HV071_RS00520	101101..101421	-	321	WP_023315132.1	TA system toxin CbtA family protein	Toxin
HV071_RS00525	101455..101820	-	366	WP_045307488.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV071_RS00530	101852..102073	-	222	WP_023315134.1	DUF987 domain-containing protein	-
HV071_RS00535	102082..102552	-	471	WP_023315135.1	DNA repair protein RadC	-
HV071_RS00540	102622..103443	-	822	WP_023315136.1	DUF945 domain-containing protein	-
HV071_RS00545	104136..104975	-	840	WP_048982768.1	hypothetical protein	-
HV071_RS00550	105035..105469	-	435	WP_181238424.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	94824..118360	23536

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-104)

Antitoxin

• Antitoxin CbeA (18-116)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12252.84 Da
• Isoelectric Point: 5.9559

>T165920 WP_023315132.1 NZ_CP058153:c101421-101101 [Enterobacter hormaechei]
MHISTVPATVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNFTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVHRVQFNLGLKRS

Nucleotide

• Length: 321 bp

>T165920 NZ_CP074001:628170-628484 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13498.28 Da
• Isoelectric Point: 6.8421

>AT165920 WP_045307488.1 NZ_CP058153:c101820-101455 [Enterobacter hormaechei]
MQSTTLSGTSAENASCLQWGLKRNITPCFGARLVQEGNRLYFLADRAGFNGSFIDDEALRLDQAFPLMMKQLERMLTTGE
LDPRSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPQSALTR

Nucleotide

• Length: 366 bp

>AT165920 NZ_CP074001:628481-628897 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA