Detailed information of TA system TA165809

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4302781..4303039
• Replicon: chromosome
• Accession: NZ_CP058057
• Organism: Escherichia fergusonii strain RHB02-C22

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: HVV54_RS20670
• Protein ID: WP_181202950.1
• Coordinates: 4302781..4302933 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4302984..4303039 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVV54_RS20645	4298645..4299355	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
HVV54_RS20650	4299793..4301163	+	1371	WP_000184983.1	MFS transporter	-
HVV54_RS20655	4301413..4301703	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HVV54_RS20660	4301985..4302197	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HVV54_RS20665	4302251..4302622	-	372	WP_001037803.1	membrane protein insertion efficiency factor YidD	-
HVV54_RS20670	4302781..4302933	-	153	WP_181202950.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4302984..4303039	+	56	-	-	Antitoxin
HVV54_RS20675	4303234..4303593	-	360	WP_141095883.1	hypothetical protein	-
HVV54_RS20680	4303662..4305731	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
HVV54_RS20685	4305741..4306652	-	912	WP_181202951.1	glycine--tRNA ligase subunit alpha	-
HVV54_RS20690	4306748..4307047	-	300	WP_024256552.1	YsaB family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5926.17 Da
• Isoelectric Point: 6.9160

>T165809 WP_181202950.1 NZ_CP058057:c4302933-4302781 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T165809 NZ_CP073974:c4062401-4062024 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT165809 NZ_CP058057:4302984-4303039 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin