Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2803790..2804292 Replicon chromosome
Accession NZ_CP058057
Organism Escherichia fergusonii strain RHB02-C22

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HVV54_RS13670 Protein ID WP_000767829.1
Coordinates 2803790..2804044 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HVV54_RS13675 Protein ID WP_001259255.1
Coordinates 2804041..2804292 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVV54_RS13640 2798805..2799032 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
HVV54_RS13645 2799046..2800104 - 1059 WP_046080827.1 transport protein YeeE -
HVV54_RS13650 2800283..2801641 - 1359 WP_059228986.1 putrescine/proton symporter PlaP -
HVV54_RS13655 2801631..2801693 - 63 WP_010723108.1 membrane protein YoeI -
HVV54_RS13660 2801908..2802837 - 930 WP_000803361.1 LysR family transcriptional regulator -
HVV54_RS13665 2802883..2803707 - 825 WP_000754745.1 SDR family oxidoreductase -
HVV54_RS13670 2803790..2804044 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HVV54_RS13675 2804041..2804292 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HVV54_RS13680 2804576..2804626 + 51 WP_001364200.1 his operon leader peptide -
HVV54_RS13685 2804772..2805671 + 900 WP_000131779.1 ATP phosphoribosyltransferase -
HVV54_RS13690 2805677..2806981 + 1305 WP_015953522.1 histidinol dehydrogenase -
HVV54_RS13695 2806978..2808048 + 1071 WP_000108922.1 histidinol-phosphate transaminase -
HVV54_RS13700 2808048..2809115 + 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T165803 WP_000767829.1 NZ_CP058057:c2804044-2803790 [Escherichia fergusonii]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T165803 NZ_CP073974:c2446752-2446579 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT165803 WP_001259255.1 NZ_CP058057:c2804292-2804041 [Escherichia fergusonii]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT165803 NZ_CP073974:c2447076-2446780 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References