Detailed information of TA system TA165698

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3852632..3852878
• Replicon: chromosome
• Accession: NZ_CP057692
• Organism: Escherichia fergusonii strain RHB17-C11

Toxin (Protein)

• Gene name: hokX
• Uniprot ID: S1PD89
• Locus tag: HVX29_RS18580
• Protein ID: WP_000956458.1
• Coordinates: 3852726..3852878 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	3852632..3852684 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVX29_RS18565	3848140..3849939	+	1800	WP_000211923.1	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	-
HVX29_RS18570	3849939..3851651	+	1713	WP_001003078.1	assimilatory sulfite reductase (NADPH) hemoprotein subunit	-
HVX29_RS18575	3851725..3852459	+	735	WP_148049224.1	phosphoadenosine phosphosulfate reductase	-
-	3852632..3852684	-	53	-	-	Antitoxin
HVX29_RS18580	3852726..3852878	+	153	WP_000956458.1	type I toxin-antitoxin system Hok family toxin	Toxin
HVX29_RS18585	3853114..3855771	+	2658	WP_002431861.1	CRISPR-associated helicase/endonuclease Cas3	-
HVX29_RS18590	3855869..3857431	+	1563	WP_001084117.1	type I-E CRISPR-associated protein Cse1/CasA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5558.77 Da
• Isoelectric Point: 7.6757

>T165698 WP_000956458.1 NZ_CP057692:3852726-3852878 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Nucleotide

• Length: 153 bp

>T165698 NZ_CP073949:846938-847345 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGTCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 53 bp

>AT165698 NZ_CP057692:c3852684-3852632 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Structures

Toxin

• AlphaFold DB: A0A4P7TJ83

Antitoxin