Detailed information of TA system TA165662

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3475576..3475834
• Replicon: chromosome
• Accession: NZ_CP057681
• Organism: Escherichia fergusonii strain RHB18-C04

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HVX35_RS16930
• Protein ID: WP_181198725.1
• Coordinates: 3475576..3475785 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3475777..3475834 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVX35_RS16910	3470641..3471228	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
HVX35_RS16915	3471262..3471828	-	567	WP_000528529.1	acetate uptake transporter	-
HVX35_RS16920	3472336..3474252	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HVX35_RS16925	3474341..3475471	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HVX35_RS16930	3475576..3475785	-	210	WP_181198725.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	3475777..3475834	+	58	-	-	Antitoxin
HVX35_RS16935	3476269..3477435	+	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
HVX35_RS16940	3477503..3478402	+	900	WP_000019049.1	transcriptional activator NhaR	-
HVX35_RS16945	3478498..3478761	-	264	WP_001274021.1	30S ribosomal protein S20	-
HVX35_RS16950	3478864..3479082	+	219	WP_181198726.1	DUF2575 domain-containing protein	-
HVX35_RS16955	3479090..3480031	+	942	WP_046081994.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T165662 WP_181198725.1 NZ_CP057681:c3475785-3475576 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICVTAIVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T165662 NZ_CP073943:1788871-1789122 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT165662 NZ_CP057681:3475777-3475834 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin