Detailed information of TA system TA165659

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2564501..2564758
• Replicon: chromosome
• Accession: NZ_CP057681
• Organism: Escherichia fergusonii strain RHB18-C04

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: F4T5C6
• Locus tag: HVX35_RS12485
• Protein ID: WP_001135731.1
• Coordinates: 2564501..2564653 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	2564710..2564758 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVX35_RS12460	2560367..2561077	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
HVX35_RS12465	2561515..2562885	+	1371	WP_104920428.1	MFS transporter	-
HVX35_RS12470	2563135..2563425	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HVX35_RS12475	2563706..2563918	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HVX35_RS12480	2563972..2564343	-	372	WP_104920427.1	membrane protein insertion efficiency factor YidD	-
HVX35_RS12485	2564501..2564653	-	153	WP_001135731.1	type I toxin-antitoxin system toxin HokA	Toxin
-	2564710..2564758	+	49	-	-	Antitoxin
HVX35_RS12490	2564975..2567044	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
HVX35_RS12495	2567054..2567965	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
HVX35_RS12500	2568061..2568360	-	300	WP_024256552.1	YsaB family lipoprotein	-
HVX35_RS12505	2568532..2569527	+	996	WP_181198556.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 6025.30 Da
• Isoelectric Point: 7.7169

>T165659 WP_001135731.1 NZ_CP057681:c2564653-2564501 [Escherichia fergusonii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T165659 NZ_CP073943:867329-867736 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 49 bp

>AT165659 NZ_CP057681:2564710-2564758 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A061YDD9

Antitoxin