Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4315822..4316080 Replicon chromosome
Accession NZ_CP057481
Organism Escherichia fergusonii strain RHB25-C10

Toxin (Protein)


Gene name hokA Uniprot ID -
Locus tag HVY20_RS20675 Protein ID WP_181202950.1
Coordinates 4315822..4315974 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 4316025..4316080 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY20_RS20650 4311686..4312396 - 711 WP_000190514.1 DUF3053 domain-containing protein -
HVY20_RS20655 4312834..4314204 + 1371 WP_000184983.1 MFS transporter -
HVY20_RS20660 4314454..4314744 + 291 WP_000455800.1 HTH-type transcriptional regulator -
HVY20_RS20665 4315026..4315238 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
HVY20_RS20670 4315292..4315663 - 372 WP_001037803.1 membrane protein insertion efficiency factor YidD -
HVY20_RS20675 4315822..4315974 - 153 WP_181202950.1 type I toxin-antitoxin system toxin HokA Toxin
- 4316025..4316080 + 56 - - Antitoxin
HVY20_RS20680 4316275..4316634 - 360 WP_141095883.1 hypothetical protein -
HVY20_RS20685 4316703..4318772 - 2070 WP_001291786.1 glycine--tRNA ligase subunit beta -
HVY20_RS20690 4318782..4319693 - 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
HVY20_RS20695 4319789..4320088 - 300 WP_024256552.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5926.17 Da        Isoelectric Point: 6.9160

>T165388 WP_181202950.1 NZ_CP057481:c4315974-4315822 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Download         Length: 153 bp

>T165388 NZ_CP073850:c467573-467385 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin


Download         Length: 56 bp

>AT165388 NZ_CP057481:4316025-4316080 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References