Detailed information of TA system TA165384

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 3830929..3831341
• Replicon: chromosome
• Accession: NZ_CP057481
• Organism: Escherichia fergusonii strain RHB25-C10

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A8D9PK47
• Locus tag: HVY20_RS18410
• Protein ID: WP_000132619.1
• Coordinates: 3831000..3831341 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	3830929..3831005 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY20_RS18400	3827824..3829413	+	1590	WP_181665716.1	type I restriction-modification system methyltransferase	-
HVY20_RS18405	3829410..3830771	+	1362	WP_181665717.1	restriction endonuclease subunit S	-
-	3830929..3831005	-	77	NuclAT_10	-	Antitoxin
-	3830929..3831005	-	77	NuclAT_10	-	Antitoxin
-	3830929..3831005	-	77	NuclAT_10	-	Antitoxin
-	3830929..3831005	-	77	NuclAT_10	-	Antitoxin
-	3830929..3831005	-	77	NuclAT_11	-	Antitoxin
-	3830929..3831005	-	77	NuclAT_11	-	Antitoxin
-	3830929..3831005	-	77	NuclAT_11	-	Antitoxin
-	3830929..3831005	-	77	NuclAT_11	-	Antitoxin
HVY20_RS18410	3831000..3831341	+	342	WP_000132619.1	endoribonuclease SymE	Toxin
HVY20_RS18415	3831503..3832882	+	1380	WP_181665718.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
HVY20_RS18420	3832882..3833928	+	1047	WP_015953744.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12322.13 Da
• Isoelectric Point: 7.8219

>T165384 WP_000132619.1 NZ_CP057481:3831000-3831341 [Escherichia fergusonii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAPEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T165384 NZ_CP073847:c1892020-1891625 [Staphylococcus epidermidis]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT165384 NZ_CP057481:c3831005-3830929 [Escherichia fergusonii]
AGTCATAACTGCTATTCTCCTGGAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin