Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 519973..520535 Replicon chromosome
Accession NZ_CP057463
Organism Escherichia fergusonii strain RHB26-C03

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVY27_RS02650 Protein ID WP_104919749.1
Coordinates 520257..520535 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HVY27_RS02645 Protein ID WP_000781370.1
Coordinates 519973..520257 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY27_RS02630 515332..518379 + 3048 WP_015953395.1 formate dehydrogenase-N subunit alpha -
HVY27_RS02635 518392..519276 + 885 WP_001240580.1 formate dehydrogenase N subunit beta -
HVY27_RS02640 519269..519922 + 654 WP_000045648.1 formate dehydrogenase-N subunit gamma -
HVY27_RS02645 519973..520257 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HVY27_RS02650 520257..520535 - 279 WP_104919749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY27_RS02655 520721..521731 - 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
HVY27_RS02660 521866..523563 - 1698 WP_000433464.1 malate dehydrogenase -
HVY27_RS02665 523720..523857 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HVY27_RS02670 523959..524174 - 216 WP_000495766.1 biofilm-dependent modulation protein -
HVY27_RS02675 524517..524948 + 432 WP_000152299.1 peroxiredoxin OsmC -
HVY27_RS02680 525009..525149 + 141 WP_109043809.1 omptin family outer membrane protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T165338 WP_104919749.1 NZ_CP057463:c520535-520257 [Escherichia fergusonii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADLDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T165338 NZ_CP073821:c467590-467402 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT165338 WP_000781370.1 NZ_CP057463:c520257-519973 [Escherichia fergusonii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT165338 NZ_CP073821:c467872-467615 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References