Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4080403..4081022 Replicon chromosome
Accession NZ_CP057459
Organism Klebsiella pneumoniae strain RHB26-C08

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HVY29_RS19865 Protein ID WP_002892050.1
Coordinates 4080804..4081022 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HVY29_RS19860 Protein ID WP_002892066.1
Coordinates 4080403..4080777 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY29_RS19850 4075555..4076748 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HVY29_RS19855 4076771..4079917 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HVY29_RS19860 4080403..4080777 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HVY29_RS19865 4080804..4081022 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HVY29_RS19870 4081181..4081747 + 567 WP_002892030.1 maltose O-acetyltransferase -
HVY29_RS19875 4081719..4081859 - 141 WP_004147370.1 hypothetical protein -
HVY29_RS19880 4081880..4082350 + 471 WP_002892026.1 YlaC family protein -
HVY29_RS19885 4082325..4083731 - 1407 WP_020316531.1 PLP-dependent aminotransferase family protein -
HVY29_RS19890 4083876..4084574 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HVY29_RS19895 4084571..4084711 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HVY29_RS19900 4084711..4084974 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T165323 WP_002892050.1 NZ_CP057459:4080804-4081022 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T165323 NZ_CP073805:1202491-1202706 [Macrococcus canis]
ATGGATCCCCAATCCAGTAGATTATTATTACAATGGATTAATAAAAATATTGTTCATTGTGAAAACCCCAGAAGCTCAGG
AAAAGCTTTGACTGGTAACTATAGTGGTATTTGGTGTTATAGAGTTGGACAATTTCGTATTATTACTAAAATAGAAGATG
ATAAATTAATTATTTTAGTAATTTCAATAGATTATAGAAAAAATATTTATCGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT165323 WP_002892066.1 NZ_CP057459:4080403-4080777 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT165323 NZ_CP073805:1202219-1202443 [Macrococcus canis]
ATGGCTACTATTACTATCAGGGTAAGTGAAGATGAAAAGAACTTTTTAAAATATATGTCAGAATTTATGAACTTAAGCTT
AACTGACTTAATTAAAAATTATACCATTGAAGATCTTGAGGATTTATTTGATACTCATGTTGCCGATAAGGCATATATTG
AATGGTCTAAACATAAGCAGACTGTTTCTCACAATGATGTTATGCAAGAATTTGGATTACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References