Detailed information of TA system TA165287

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 555326..555584
• Replicon: chromosome
• Accession: NZ_CP057458
• Organism: Escherichia fergusonii strain RHB26-C09

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HVY30_RS02755
• Protein ID: WP_000935262.1
• Coordinates: 555326..555535 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	555527..555584 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY30_RS02735	550392..550979	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
HVY30_RS02740	551013..551579	-	567	WP_000528529.1	acetate uptake transporter	-
HVY30_RS02745	552087..554003	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HVY30_RS02750	554092..555222	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HVY30_RS02755	555326..555535	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	555527..555584	+	58	-	-	Antitoxin
HVY30_RS02760	556019..557185	+	1167	WP_046076806.1	Na+/H+ antiporter NhaA	-
HVY30_RS02765	557253..558152	+	900	WP_000019049.1	transcriptional activator NhaR	-
HVY30_RS02770	558248..558511	-	264	WP_001274021.1	30S ribosomal protein S20	-
HVY30_RS02775	558614..558832	+	219	WP_012599853.1	DUF2575 family protein	-
HVY30_RS02780	558840..559781	+	942	WP_046081994.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T165287 WP_000935262.1 NZ_CP057458:c555535-555326 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T165287 NZ_CP073789:89773-90255 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT165287 NZ_CP057458:555527-555584 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin