Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 61083..61630 Replicon chromosome
Accession NZ_CP057330
Organism Klebsiella oxytoca strain RHB30-C02

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag HVY70_RS00305 Protein ID WP_064344021.1
Coordinates 61083..61391 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag HVY70_RS00310 Protein ID WP_064344020.1
Coordinates 61394..61630 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY70_RS00275 56730..57041 - 312 WP_004107048.1 PTS sugar transporter subunit IIB -
HVY70_RS00280 57336..58277 + 942 WP_064344024.1 LacI family transcriptional regulator -
HVY70_RS00285 58301..58594 - 294 WP_064344023.1 hypothetical protein -
HVY70_RS00290 58808..59770 + 963 WP_064344105.1 Rpn family recombination-promoting nuclease/putative transposase -
HVY70_RS00295 59770..60027 + 258 WP_064344022.1 hypothetical protein -
HVY70_RS00300 60031..60933 - 903 WP_004107039.1 DMT family transporter -
HVY70_RS00305 61083..61391 - 309 WP_064344021.1 CcdB family protein Toxin
HVY70_RS00310 61394..61630 - 237 WP_064344020.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HVY70_RS00315 61736..63169 - 1434 WP_064344019.1 PTS N-acetylmuramic acid transporter subunit IIBC -
HVY70_RS00320 63194..64096 - 903 WP_064344104.1 N-acetylmuramic acid 6-phosphate etherase -
HVY70_RS00325 64258..65424 - 1167 WP_064344018.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11726.51 Da        Isoelectric Point: 6.2188

>T165223 WP_064344021.1 NZ_CP057330:c61391-61083 [Klebsiella oxytoca]
MQYYVYKNTGRIAAYPYLLDVQSDIIGERNTRVVIPLFPLKNYKGPRADRLTPLVTVEGEEYVVMTHELASIPHRVLGEE
VCNLNHQREVVKASMDFLFDGI

Download         Length: 309 bp

>T165223 NZ_CP073768:c2476944-2476768 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8768.95 Da        Isoelectric Point: 5.7928

>AT165223 WP_064344020.1 NZ_CP057330:c61630-61394 [Klebsiella oxytoca]
MPAAKRNKQNVSVTLDPGLVKQAREVGINLSLTLTNALKSEIHSLEIARWQKENALAIDYLNNLTEENGLLSDEYRTF

Download         Length: 237 bp

>AT165223 NZ_CP073768:c2476722-2476306 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References