Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4393490..4394075 Replicon chromosome
Accession NZ_CP057258
Organism Citrobacter freundii strain RHB31-C16

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HVY90_RS20735 Protein ID WP_135912739.1
Coordinates 4393490..4393804 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HVY90_RS20740 Protein ID WP_115259723.1
Coordinates 4393797..4394075 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY90_RS20710 4389604..4391184 + 1581 WP_181688573.1 RNA repair transcriptional activator RtcR -
HVY90_RS20715 4391289..4391561 + 273 WP_181596016.1 DUF3811 domain-containing protein -
HVY90_RS20720 4391558..4392433 - 876 WP_137399222.1 23S rRNA pseudouridine(2604) synthase RluF -
HVY90_RS20725 4392684..4393001 - 318 WP_181688574.1 CcdB family protein -
HVY90_RS20730 4393001..4393294 - 294 WP_174361424.1 type II toxin-antitoxin system CcdA family antitoxin -
HVY90_RS20735 4393490..4393804 + 315 WP_135912739.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY90_RS20740 4393797..4394075 + 279 WP_115259723.1 putative addiction module antidote protein Antitoxin
HVY90_RS20745 4394187..4394876 + 690 WP_115259724.1 dipeptidase PepE -
HVY90_RS20750 4395005..4396636 - 1632 WP_117343624.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-94)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11969.88 Da        Isoelectric Point: 9.5570

>T165146 WP_135912739.1 NZ_CP057258:4393490-4393804 [Citrobacter freundii]
MEILQTMVFQRWEQNLRDRRAKTLIATRLFRLANGLAGDVKPVGEGISEMRISYGPGYRIYFKQQGCHIIILLCGGDKSS
QANDITMAKMLARSLDYQEIRHHE

Download         Length: 315 bp

>T165146 NZ_CP073719:c68943-68650 [Escherichia coli]
ATGGCTGTCGAGTTTAGAGACACGTGGCTGGAAGCGTTTTACGAGGATGACCAAAACCACAGGAGGATACCTAGTACCAT
CGAAGGCGCATTGTTCAGGAAGCTGGAGATCTTGGACGCAGCGACCCAGGAGTCAGACTTGAGAATCCCTCCGGGTAACC
GCTTCGAGCACCTTGAAGGGAATATGGCCGGGTGGTGTTCCATCCGGGTAAACAAGCAATACCGGCTGATCTTTAGATGG
ATCGATGGCGTTGCCCAAGATACTTATCTGGATCCTCATGTTTACAGGGGCTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9863.44 Da        Isoelectric Point: 6.3200

>AT165146 WP_115259723.1 NZ_CP057258:4393797-4394075 [Citrobacter freundii]
MNKLTRYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKALGIELTLKK

Download         Length: 279 bp

>AT165146 NZ_CP073719:c68635-68309 [Escherichia coli]
ATGAGAAACACAAAACGTCGCCCAGTTACGGTCGGTCAGATGCTGGTAACCGAGTTCCTGGAGCCTATGAACATCGAGAT
CAACGAACTGGCTGAAGCCATGGGTGTGCACAGAAACACCCTGAGTCGGATCGTTCACGACAAGGGGGCATTGACCGCAC
CCATGTCAATCAAACTGGCAGCGGCCTTGGGTAACACGCCGGAGTTCTGGCTCAATATTCAGCACTCAGTAGAGTTGTGG
GATGTTCGGCATAGAGCCTTTGAGCAGGAAGCAAAGAATGTTAAACGAGTAACGCCTCACTTGGAGAACAGGGAAGCAGT
TATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References