Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 138286..138929 Replicon plasmid pRHB32-C05_2
Accession NZ_CP057244
Organism Escherichia fergusonii strain RHB32-C05

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag HVY96_RS23595 Protein ID WP_097418959.1
Coordinates 138513..138929 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag HVY96_RS23590 Protein ID WP_097309516.1
Coordinates 138286..138516 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY96_RS23555 133743..134135 - 393 WP_000340833.1 plasmid partitioning/stability family protein -
HVY96_RS23560 134140..135111 - 972 WP_097418955.1 plasmid segregation protein parM -
HVY96_RS23565 135340..135984 + 645 WP_000633911.1 AAA family ATPase -
HVY96_RS23570 135978..136253 + 276 WP_097418957.1 CopG family transcriptional regulator -
HVY96_RS23575 136391..137200 - 810 WP_097418958.1 site-specific integrase -
HVY96_RS23580 137201..137506 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB -
HVY96_RS23585 137508..137726 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA -
HVY96_RS23590 138286..138516 + 231 WP_097309516.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HVY96_RS23595 138513..138929 + 417 WP_097418959.1 type II toxin-antitoxin system VapC family toxin Toxin
HVY96_RS23600 138974..142768 - 3795 WP_175616550.1 pcar -
HVY96_RS23605 143117..143374 + 258 WP_000343099.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - pefD / pefC / pefA 1..147532 147532


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14948.29 Da        Isoelectric Point: 6.7113

>T165101 WP_097418959.1 NZ_CP057244:138513-138929 [Escherichia fergusonii]
VNKIYMLDTNICSFIMREQPEAVLKNLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEVKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFERVPGLVLEDWAG

Download         Length: 417 bp

>T165101 NZ_CP073704:1250172-1250579 [Burkholderia cenocepacia]
ATGAAGTTCCTCCTGGATACCAACGCGGTGATCGCCATTCTCAAAGGCGAGCCGGCGATACTGGCCCGTTTGCATGCCTG
GCACCCGGCCGATTTCGGGATCCCCGCGATCGTCGCGCACGAGCTTTACTACGGCGCGTACAAGAGCCAGCGAGCGGCTG
CGAACGTCGCGCGTGTCGACGCGCTGCAGTTCGAGGTCGTATCGTTCGACACCGAGGATGCACAGCATGCGGGTGAAATT
CGTGCGCACCTGATCGCGGCCGGCACGCCGATCGGTCCATACGATGCATTGATCGCAGGGCAGGCGCGCGCGCGGCAACT
GGTGCTGGTCACGCACAACGTTCGCGAATTCGAGCGCGTTCCGCGGCTGCAATTCGAAGACTGGCTAGCCGAACCGAGGG
CAGACTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8811.02 Da        Isoelectric Point: 4.6282

>AT165101 WP_097309516.1 NZ_CP057244:138286-138516 [Escherichia fergusonii]
MRTVSIFKNGNNRAIRLPRELDFEGVSELEIIREGNSIILRPVRPTWSSFLELEKADPGFMTEREDVVCDEGRFNL

Download         Length: 231 bp

>AT165101 NZ_CP073704:1249933-1250175 [Burkholderia cenocepacia]
ATGGATACTGCAAAGCTCTTCAAGCATGGTGGCTCGCAGGCTGTCCGGCTGCCGAAGGATTTCCGCTTCGATACGGCCGA
GGTTCGCATCCGCCGCCACGGGGCGGCCGTCATTCTCGAGCCGATGCCGCAAGACTGGGCTTGGCTGGCACCGCTGATCG
GTCCAGTGGACGCCGATTTCGAGGCTGCCGCGACCACACAGCCGTCCGCTCAGGAGCGCTCGGGCCTGGACGTGTTCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References