Detailed information of TA system TA165088

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sib/Ldr(toxin)
• Location: 4429787..4430006
• Replicon: chromosome
• Accession: NZ_CP057243
• Organism: Escherichia fergusonii strain RHB32-C05

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: HVY96_RS21610
• Protein ID: WP_001295224.1
• Coordinates: 4429787..4429894 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sib
Locus tag	-
Coordinates	4429943..4430006 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY96_RS21585	4425329..4425517	-	189	WP_001063310.1	YhjR family protein	-
HVY96_RS21590	4425804..4427363	+	1560	WP_001070267.1	cellulose biosynthesis protein BcsE	-
HVY96_RS21595	4427360..4427551	+	192	WP_000981122.1	cellulose biosynthesis protein BcsF	-
HVY96_RS21600	4427548..4429227	+	1680	WP_000192007.1	cellulose biosynthesis protein BcsG	-
HVY96_RS21605	4429314..4429421	-	108	WP_114091462.1	type I toxin-antitoxin system toxin Ldr family protein	-
HVY96_RS21610	4429787..4429894	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4429943..4430006	+	64	NuclAT_12	-	Antitoxin
-	4429943..4430006	+	64	NuclAT_12	-	Antitoxin
-	4429943..4430006	+	64	NuclAT_12	-	Antitoxin
-	4429943..4430006	+	64	NuclAT_12	-	Antitoxin
-	4429943..4430006	+	64	NuclAT_13	-	Antitoxin
-	4429943..4430006	+	64	NuclAT_13	-	Antitoxin
-	4429943..4430006	+	64	NuclAT_13	-	Antitoxin
-	4429943..4430006	+	64	NuclAT_13	-	Antitoxin
-	4429943..4430006	+	64	NuclAT_14	-	Antitoxin
-	4429943..4430006	+	64	NuclAT_14	-	Antitoxin
-	4429943..4430006	+	64	NuclAT_14	-	Antitoxin
-	4429943..4430006	+	64	NuclAT_14	-	Antitoxin
-	4429943..4430006	+	64	NuclAT_15	-	Antitoxin
-	4429943..4430006	+	64	NuclAT_15	-	Antitoxin
-	4429943..4430006	+	64	NuclAT_15	-	Antitoxin
-	4429943..4430006	+	64	NuclAT_15	-	Antitoxin
-	4429943..4430008	+	66	NuclAT_10	-	-
-	4429943..4430008	+	66	NuclAT_10	-	-
-	4429943..4430008	+	66	NuclAT_10	-	-
-	4429943..4430008	+	66	NuclAT_10	-	-
-	4429943..4430008	+	66	NuclAT_11	-	-
-	4429943..4430008	+	66	NuclAT_11	-	-
-	4429943..4430008	+	66	NuclAT_11	-	-
-	4429943..4430008	+	66	NuclAT_11	-	-
HVY96_RS21615	4430331..4431527	+	1197	WP_181666930.1	methionine gamma-lyase	-
HVY96_RS21620	4431777..4433075	+	1299	WP_181666931.1	amino acid permease	-
HVY96_RS21625	4433091..4433690	-	600	Protein_4217	sigma 54-interacting transcriptional regulator	-
HVY96_RS21630	4433749..4434446	+	698	Protein_4218	IS1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4433749..4434024	275

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T165088 WP_001295224.1 NZ_CP057243:c4429894-4429787 [Escherichia fergusonii]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T165088 NZ_CP073678:c123395-123024 [Cupriavidus sp. KK10]
ATGATTCTTGTCGACACGTCGGTCTGGATTGACCACATCAACGCTTCTGATCCTGTGCTGATTAGCCTGCTTGCCGAGGA
GCGTGTGCTGGCTCATCCATATGTGATAGGCGAGATTTCGCTCAGTAGTCTGCGTGACCGTGACGTCGTGCTTGGCGCGT
TGCTCGATCTGCCGCGCGCGCCAGTTGTAACGCCGGAGGAGACGTTCTATCTGATCGAGCGCGAAGGTTTGTTCAATCGT
GGAATCGGATATGTCGACACGTCACTGTTGGCGTCCGCGCGCCTACAACCAGGCATCACCATCTGGACGCGCGACAAGCG
ATTGAAGAAAGTTGCCGATGAACTCAATCTCGGCGCGGTGCTCGCGCACTAG

Antitoxin

Nucleotide

• Length: 64 bp

>AT165088 NZ_CP057243:4429943-4430006 [Escherichia fergusonii]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin