Detailed information of TA system TA165065

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 714805..715063
• Replicon: chromosome
• Accession: NZ_CP057243
• Organism: Escherichia fergusonii strain RHB32-C05

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HVY96_RS03535
• Protein ID: WP_000935262.1
• Coordinates: 714805..715014 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	715006..715063 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY96_RS03515	709871..710458	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
HVY96_RS03520	710492..711058	-	567	WP_000528529.1	acetate uptake transporter	-
HVY96_RS03525	711566..713482	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HVY96_RS03530	713571..714701	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HVY96_RS03535	714805..715014	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	715006..715063	+	58	-	-	Antitoxin
HVY96_RS03540	715498..716664	+	1167	WP_046076806.1	Na+/H+ antiporter NhaA	-
HVY96_RS03545	716732..717631	+	900	WP_000019049.1	transcriptional activator NhaR	-
HVY96_RS03550	717727..717990	-	264	WP_001274021.1	30S ribosomal protein S20	-
HVY96_RS03555	718093..718311	+	219	WP_046076805.1	DUF2575 family protein	-
HVY96_RS03560	718319..719260	+	942	WP_046081994.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T165065 WP_000935262.1 NZ_CP057243:c715014-714805 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T165065 NZ_CP073671:131865-132158 [Burkholderia cenocepacia]
ATGAGAATCGAGCAGACAGACGACTTCGCGAAATGGTTGCGCGGCCTACGCGACCACATCGCGCGCGCGCAGATCGCCAA
GCGGATTCAACGGCTCGCGCGCGGCCAGTACGGGGACGTGAAGTCGGTTGGTTCCGGCGTGAGCGAAATGCGCGTGCACG
TCGGCCCCGGCTATCGCGTCTACTTTGTCCAACGGGGCTCAACGCTTGTCGTCCTGCTCTGCGGTGGCGACAAGTCAACG
CAGCAGCGCGACATTGAGCGCGCTATCGCGCTTTCGACGCAATTGGGAGATTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT165065 NZ_CP057243:715006-715063 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin