Detailed information of TA system TA165019

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3772595..3772841
• Replicon: chromosome
• Accession: NZ_CP057229
• Organism: Escherichia fergusonii strain RHB32-C16

Toxin (Protein)

• Gene name: hokX
• Uniprot ID: S1PD89
• Locus tag: HVZ03_RS18145
• Protein ID: WP_000956458.1
• Coordinates: 3772689..3772841 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	3772595..3772647 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ03_RS18130	3768103..3769902	+	1800	WP_000211943.1	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	-
HVZ03_RS18135	3769902..3771614	+	1713	WP_046083135.1	assimilatory sulfite reductase (NADPH) hemoprotein subunit	-
HVZ03_RS18140	3771688..3772422	+	735	WP_046083134.1	phosphoadenosine phosphosulfate reductase	-
-	3772595..3772647	-	53	-	-	Antitoxin
HVZ03_RS18145	3772689..3772841	+	153	WP_000956458.1	type I toxin-antitoxin system Hok family toxin	Toxin
HVZ03_RS18150	3773077..3775734	+	2658	WP_181668202.1	CRISPR-associated helicase Cas3'	-
HVZ03_RS18155	3775832..3777394	+	1563	WP_181668203.1	type I-E CRISPR-associated protein Cse1/CasA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5558.77 Da
• Isoelectric Point: 7.6757

>T165019 WP_000956458.1 NZ_CP057229:3772689-3772841 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Nucleotide

• Length: 153 bp

>T165019 NZ_CP073637:157950-158351 [Burkholderia cepacia]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGTTGAAGAATCAGCCGGAACAGGTCGCGAGGCGATTTGC
ACAGTGCTACACGGGGGACGTCGTGATGTCGGCGATTACCTATGCCGAGCTCGAGTACGGTGTGACCGCGTGTACAAGTC
CTGCCCAGGAGCGCAGCAATCTCGCCGCGCTGATCGAGGATATTCCGGTCGCGCCGTTCGACGCGGTGGCCGCGCAAGCG
TACGGCTCTGTCCGCGAAGCGACCCGCGAACGGAAGAGGGATCATCTCGACAAACTGATCGCGGCTCATGCGGTGTCGCT
CGACGTCGTGCTGGTGACCAACAACGAGCGGGATTTCGTGAGCTATCCGGGCGTGCGGCTGGAGAACTGGTTGAACGACT
AG

Antitoxin

Nucleotide

• Length: 53 bp

>AT165019 NZ_CP057229:c3772647-3772595 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Structures

Toxin

• AlphaFold DB: A0A4P7TJ83

Antitoxin