Detailed information of TA system TA164974

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 679372..679630
• Replicon: chromosome
• Accession: NZ_CP057220
• Organism: Escherichia fergusonii strain RHB32-C22

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HVZ07_RS03325
• Protein ID: WP_181668149.1
• Coordinates: 679372..679581 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	679573..679630 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ07_RS03305	674437..675024	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
HVZ07_RS03310	675058..675624	-	567	WP_000528529.1	acetate uptake transporter	-
HVZ07_RS03315	676132..678048	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HVZ07_RS03320	678137..679267	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HVZ07_RS03325	679372..679581	-	210	WP_181668149.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	679573..679630	+	58	-	-	Antitoxin
HVZ07_RS03330	680065..681231	+	1167	WP_046076806.1	Na+/H+ antiporter NhaA	-
HVZ07_RS03335	681299..682198	+	900	WP_000019049.1	transcriptional activator NhaR	-
HVZ07_RS03340	682294..682557	-	264	WP_001274021.1	30S ribosomal protein S20	-
HVZ07_RS03345	682660..682878	+	219	WP_046076805.1	DUF2575 family protein	-
HVZ07_RS03350	682886..683827	+	942	WP_000767324.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (26-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7752.30 Da
• Isoelectric Point: 9.3680

>T164974 WP_181668149.1 NZ_CP057220:c679581-679372 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAIIVALIVICITAVVVALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T164974 NZ_CP073624:1121920-1122231 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT164974 NZ_CP057220:679573-679630 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin